| Innate immune function of the human decidual cell at the maternal-fetal interface. | |
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MedLine Citation:
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PMID: 17196257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study was to investigate the innate immune function of decidual cells from term unlabored pregnancies by determining Toll-like receptor presence and function. Using immunohistochemistry, reverse transcriptase polymerase chain reaction and NF-kappaB-luciferase plasmid transfection, Toll-like receptor presence and function was determined. Decidual cells express Toll-like receptors 1, 2, 4 and 6 which respond to lipopolysaccharide and peptidoglycan stimulation producing Interleukin-8. Decidual cells from women at term have innate immune function and are capable of producing Interleukin responses to bacterial ligands. |
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Authors:
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Timothy P Canavan; Hyagriv N Simhan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-12-28 |
Journal Detail:
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Title: Journal of reproductive immunology Volume: 74 ISSN: 0165-0378 ISO Abbreviation: J. Reprod. Immunol. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-09 Completed Date: 2007-07-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8001906 Medline TA: J Reprod Immunol Country: Ireland |
Other Details:
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Languages: eng Pagination: 46-52 Citation Subset: IM |
Affiliation:
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University of Pittsburgh School of Medicine, Magee Womens Hospital, Department of Obstetrics, Gynecology and Reproductive Sciences, 300 Halket Street, Pittsburgh, PA 15213, USA. timothyc@greenhosp.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Decidua
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cytology,
immunology* Enzyme-Linked Immunosorbent Assay Female Humans Immunity, Innate* Immunohistochemistry Interleukin-8 / immunology*, metabolism Lipopolysaccharides / immunology* NF-kappa B / genetics, metabolism Peptidoglycan / immunology* Pregnancy Reverse Transcriptase Polymerase Chain Reaction Toll-Like Receptors / immunology, metabolism*, physiology Transfection |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-8; 0/Lipopolysaccharides; 0/NF-kappa B; 0/Peptidoglycan; 0/Toll-Like Receptors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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