Document Detail


Innate immune function of the human decidual cell at the maternal-fetal interface.
MedLine Citation:
PMID:  17196257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to investigate the innate immune function of decidual cells from term unlabored pregnancies by determining Toll-like receptor presence and function. Using immunohistochemistry, reverse transcriptase polymerase chain reaction and NF-kappaB-luciferase plasmid transfection, Toll-like receptor presence and function was determined. Decidual cells express Toll-like receptors 1, 2, 4 and 6 which respond to lipopolysaccharide and peptidoglycan stimulation producing Interleukin-8. Decidual cells from women at term have innate immune function and are capable of producing Interleukin responses to bacterial ligands.
Authors:
Timothy P Canavan; Hyagriv N Simhan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-28
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  74     ISSN:  0165-0378     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-09     Completed Date:  2007-07-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  46-52     Citation Subset:  IM    
Affiliation:
University of Pittsburgh School of Medicine, Magee Womens Hospital, Department of Obstetrics, Gynecology and Reproductive Sciences, 300 Halket Street, Pittsburgh, PA 15213, USA. timothyc@greenhosp.org
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MeSH Terms
Descriptor/Qualifier:
Decidua / cytology,  immunology*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunity, Innate*
Immunohistochemistry
Interleukin-8 / immunology*,  metabolism
Lipopolysaccharides / immunology*
NF-kappa B / genetics,  metabolism
Peptidoglycan / immunology*
Pregnancy
Reverse Transcriptase Polymerase Chain Reaction
Toll-Like Receptors / immunology,  metabolism*,  physiology
Transfection
Chemical
Reg. No./Substance:
0/Interleukin-8; 0/Lipopolysaccharides; 0/NF-kappa B; 0/Peptidoglycan; 0/Toll-Like Receptors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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