Document Detail


Innate immune defense system of the skin.
MedLine Citation:
PMID:  23331677     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Antimicrobial peptides (AMPs) have a pivotal role in cutaneous innate immunity. They are present in the skin of many animals, including mammals, and are both constitutively present and inducible by infection and injury.
FUNCTIONS: Antimicrobial peptides exhibit antimicrobial activity against bacteria, viruses, fungi and parasites, with different potencies depending on their peptide structure. They also act as multifunctional effector molecules that influence diverse cellular processes, including cell migration, proliferation and differentiation, cytokine production, angiogenesis and wound healing. Suppressed AMP production has been associated with increased susceptibility to microbial insults and the pathogenesis of atopic dermatitis. This review highlights recent observations on the expression and role of AMPs, particularly the AMPs cathelicidin and β-defensin, in healthy and diseased skin.
Authors:
Maryam Afshar; Richard L Gallo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Veterinary dermatology     Volume:  24     ISSN:  1365-3164     ISO Abbreviation:  Vet. Dermatol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-07-03     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  9426187     Medline TA:  Vet Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  32-8.e8-9     Citation Subset:  IM    
Copyright Information:
© 2013 The Authors. Veterinary Dermatology © 2013 ESVD and ACVD.
Affiliation:
Division of Dermatology, Department of Medicine, University of California, San Diego, 8899 University Center Lane, San Diego, CA 92122, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Gene Expression Regulation
Immunity, Innate / physiology*
Skin / immunology*,  metabolism*
Grant Support
ID/Acronym/Agency:
R01 AI052453/AI/NIAID NIH HHS; R01 AI0833358/AI/NIAID NIH HHS; R01 AR052728/AR/NIAMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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