| Innate immune activation in primary HIV-1 infection. | |
| | |
MedLine Citation:
|
PMID: 20846036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
There is growing evidence that highlights the role of the immune response during acute human immunodeficiency virus type 1 (HIV-1) infection in the control or development of disease. The adaptive immune responses do not appear until after HIV-1 infection is already well established, so the role of earlier and faster-responding innate immunity needs to be more closely scrutinized. In particular, 2 aspects of innate immunity for which there are growing research developments will be examined in this review: the actions of type I interferons and natural killer cells. These two components of the innate immune response contribute to viral control both by killing infected cells and by modulating other immune cells that develop. However, the role of interferon α in immune activation is a double-edged sword, causing recruitment of adaptive immune cells that can assist in viral control but concurrently contributing to immune activation-dependent disease progression. Understanding the complexity of how innate responses affect the outcome of HIV-1 infection will help in the development of vaccines that can use innate immunity to enhance viral control with minimal pathogenesis. |
| | |
Authors:
|
J Judy Chang; Marcus Altfeld |
Related Documents
:
|
19372796 - Macrophages and residual hiv infection. 20625436 - Unexpected diversity of cellular immune responses against nef and vif in hiv-1-infected... 11240016 - Reduction in glial immunity and neuropathology by a paf antagonist and an mmp and tnfal... 19286896 - Effects of hiv-1 infection in vitro on transendothelial migration by monocytes and mono... 7947826 - Purification, bioactivity, and secondary structure analysis of mouse and human macropha... 22076446 - Identification of a methylation hotspot in the death receptor fas/cd95 in b... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: The Journal of infectious diseases Volume: 202 Suppl 2 ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-17 Completed Date: 2010-10-06 Revised Date: 2011-10-17 |
Medline Journal Info:
|
Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
|
Languages: eng Pagination: S297-301 Citation Subset: AIM; IM |
Affiliation:
|
Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02129, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
HIV Infections
/
immunology*,
virology HIV-1 / immunology* Humans Immunity, Innate* Interferon Type I / immunology Killer Cells, Natural / immunology |
| Grant Support | |
ID/Acronym/Agency:
|
P01 AI074415-01A2/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Interferon Type I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: HIV-1 transmission biology: selection and characteristics of infecting viruses.
Next Document: T cell immunity in acute HIV-1 infection.