| Innate helper cells: a novel cell type essential in the initiation of asthma? | |
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MedLine Citation:
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PMID: 21680565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of the innate immune system in asthma initiation is being increasingly recognised, and several innate epithelial cytokines, such as interleukin 33 (IL-33), IL-25 and thymic stromal lymphopoietin, have been described as important in asthma pathogenesis. However, until now, the mechanism by which these cytokines initiate Th2 responses and form a link with the adaptive immune system was undetermined. The recent discovery of a new group of non-T, non-B innate helper cells, which are induced by epithelial innate cytokines and secrete the Th2 cytokines IL-4 and IL-13, may provide a mechanism by which the innate and adaptive immune systems become activated in asthma. |
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Authors:
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Sejal Saglani |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-06-15 |
Journal Detail:
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Title: Thorax Volume: 66 ISSN: 1468-3296 ISO Abbreviation: Thorax Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-18 Completed Date: 2011-11-02 Revised Date: 2013-02-11 |
Medline Journal Info:
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Nlm Unique ID: 0417353 Medline TA: Thorax Country: England |
Other Details:
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Languages: eng Pagination: 834-5 Citation Subset: IM |
Affiliation:
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Wellcome Intermediate Clinical Fellow, Clinical Senior Lecturer Respiratory Paediatrics, Imperial College London, 374 Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, UK. s.saglani@imperial.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Asthma / immunology*, pathology Cytokines / immunology*, metabolism Humans Immunity, Innate* Th2 Cells / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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083586//Wellcome Trust; 083586/Z/07/Z//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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