Document Detail

Innate and adaptive immune gene expression profiles as biomarkers in human type 1 diabetes.
MedLine Citation:
PMID:  23039883     Owner:  NLM     Status:  MEDLINE    
The mRNA levels of a set of immune-related genes were analysed with peripheral blood samples from at-risk, new-onset and long-term type 1 diabetes (T1D) patients, in comparison to those from healthy controls. The selected set includes T lymphocyte genes [CD3G and cytotoxic T lymphocyte-associated antigen 4 (CTLA4)], B lymphocyte genes (CD19 and CD20) and myeloid cell-related genes [CD11b, Toll-like receptor (TLR)-9, arginase (ARG1)]. Also included is a subset of the S100 family members that has been documented recently as regulatory elements of innate immunity. Samples from patients with long-term T1D had a reduced level of mRNA for most of selected innate and adaptive immune genes. No such reduction was detected in samples collected from at-risk or new-onset T1D patients. Analyses of regulatory gene expression ratios revealed a dynamic disproportion of CTLA4 versus CD3G expression in samples from at-risk, new-onset and long-term T1D patients. These changes could serve as immunological biomarkers for the status of the immune system during T1D progression and therapeutic interventions.
D Han; X Cai; J Wen; D Matheson; J S Skyler; N S Kenyon; Z Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  170     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-08     Completed Date:  2013-03-18     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  131-8     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology.
Department of Microbiology and Immunology, RMSB 3035, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA.
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MeSH Terms
Adaptive Immunity / genetics,  immunology
Antigens, CD / blood,  genetics,  immunology,  metabolism
Arginase / blood,  genetics,  immunology,  metabolism
Biological Markers / blood
CTLA-4 Antigen / blood,  genetics,  immunology,  metabolism
Diabetes Mellitus, Type 1 / blood,  genetics*,  immunology*,  metabolism
Gene Expression Profiling / methods
Gene Expression Regulation / genetics,  immunology
Immunity, Innate / genetics,  immunology
Middle Aged
RNA, Messenger / genetics,  immunology
S100 Proteins / blood,  genetics,  immunology,  metabolism
T-Lymphocytes / immunology,  metabolism
Toll-Like Receptor 9 / blood,  genetics,  immunology,  metabolism
Young Adult
Grant Support
Reg. No./Substance:
0/Antigens, CD; 0/Biological Markers; 0/CTLA-4 Antigen; 0/CTLA4 protein, human; 0/RNA, Messenger; 0/S100 Proteins; 0/TLR9 protein, human; 0/Toll-Like Receptor 9; EC

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