Document Detail

Innate NKTγδ and NKTαβ cells exert similar functions and compete for a thymic niche.
MedLine Citation:
PMID:  22539299     Owner:  NLM     Status:  In-Data-Review    
The transcriptional regulator promyelocytic leukemia zinc finger (PLZF) is highly expressed during the differentiation of natural killer T (NKT) cells and is essential for the acquisition of their effector/memory innate-like phenotype. Staining with anti-PLZF and anti-NK1.1 Abs allows the definition of two subsets of NKTαβ and NKTγδ thymocytes that differ phenotypically and functionally: a PLZF(+) NK1.1(-) subset composed of mostly quiescent cells that secrete more IL-4 than IFN-γ upon activation and a PLZF(+/-) NK1.1(+) subset that expresses CD127, NK1.1, and other NK-cell markers, secrete more IFN-γ than IL-4 upon activation and contains a sizable fraction of dividing cells. The size of the NK1.1(+) population is very tightly regulated and NK1.1(+) αβ and γδ thymocytes compete for a thymic niche. Furthermore, the relative representation of the PLZF(+) and NK1.1(+) subsets varies in a strain-specific manner with C57BL/6 (B6) mice containing more NK1.1(+) cells and (B6 × DBA/2)F1 (B6D2F1) mice more PLZF(+) cells. Consequently, activation of NKT cells in vivo is expected to result in higher levels of IL-4 secreted in B6D2F1 mice than in B6 mice. Consistent with this possibility, B6D2F1 mice, when compared with B6 mice, contain more "innate" CD8(+) thymocytes, the generation of which depends on IL-4 secreted by NKT cells.
Pablo Pereira; Laurent Boucontet
Related Documents :
12881479 - Circulating vascular progenitor cells do not contribute to compensatory lung growth.
17101709 - Il9 leads to airway inflammation by inducing il13 expression in airway epithelial cells.
7925899 - Procoagulant activity of bronchoalveolar lavage fluids taken from the site of tuberculo...
11428739 - Distribution and cytokine production of cd4 and cd8 t-lymphocyte subsets in patients wi...
1426219 - Effects of repeated exposure to 4 ppm nitrogen dioxide on bronchoalveolar lymphocyte su...
1646269 - Enhanced reactive oxygen species metabolism of air space cells in hypersensitivity pneu...
24371229 - Curcumin targets breast cancer stem-like cells with microtentacles that persist in mamm...
12494879 - Growth factors, cytokines, chemokines and neuropeptides in the modeling of t-cells.
9143939 - A polypeptide encoded within the murine aids defective virus stimulates primary prolife...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of immunology     Volume:  42     ISSN:  1521-4141     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1272-81     Citation Subset:  IM    
Copyright Information:
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Institut Pasteur, Unité Limphopoïese, INSERM U668, Paris, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  NKp46 expression discriminates porcine NK cells with different functional properties.
Next Document:  Glucocorticoid-induced leucine zipper is downregulated in human alveolar macrophages upon Toll-like ...