| Innate immune signaling in the myelodysplastic syndromes. | |
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MedLine Citation:
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PMID: 20359630 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myelodysplastic syndromes (MDS) are heterogeneous clonal hematologic malignancies characterized by cytopenias caused by ineffective hematopoiesis and propensity to progress to acute myeloid leukemia. Innate immunity provides immediate protection against pathogens by coordinating activation of signaling pathways in immune cells. Given the prominent role of the innate immune pathway in regulating hematopoiesis, it is not surprising that aberrant signaling of this pathway is associated with hematologic malignancies. Increased activation of the innate immune pathway may contribute to dysregulated hematopoiesis, dysplasia, and clonal expansion in myelodysplastic syndromes. |
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Authors:
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Daniel T Starczynowski; Aly Karsan |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Hematology/oncology clinics of North America Volume: 24 ISSN: 1558-1977 ISO Abbreviation: Hematol. Oncol. Clin. North Am. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-02 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709473 Medline TA: Hematol Oncol Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 343-59 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Genome Sciences Centre, British Columbia Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Transformation, Neoplastic / genetics Cytokines / biosynthesis, genetics Gene Expression Regulation / immunology Genes, MHC Class II Hematopoiesis / immunology Hematopoietic Stem Cells / cytology, immunology Humans Immunity, Innate* / genetics Inflammation / immunology Leukemia, Myeloid, Acute / genetics, immunology Mice MicroRNAs / genetics Myelodysplastic Syndromes / genetics, immunology* Receptors, Immunologic / immunology Receptors, Tumor Necrosis Factor / immunology Toll-Like Receptors / immunology |
| Grant Support | |
ID/Acronym/Agency:
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MOP 89976//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/MicroRNAs; 0/Receptors, Immunologic; 0/Receptors, Tumor Necrosis Factor; 0/Toll-Like Receptors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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