| Innate immune activation during Salmonella infection initiates extramedullary erythropoiesis and splenomegaly. | |
| | |
MedLine Citation:
|
PMID: 20952675 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Systemic Salmonella infection commonly induces prolonged splenomegaly in murine or human hosts. Although this increase in splenic cellularity is often assumed to be due to the recruitment and expansion of leukocytes, the actual cause of splenomegaly remains unclear. We monitored spleen cell populations during Salmonella infection and found that the most prominent increase is found in the erythroid compartment. At the peak of infection, the majority of spleen cells are immature CD71(-)Ter119(+) reticulocytes, indicating that massive erythropoiesis occurs in response to Salmonella infection. Indeed, this increase in RBC precursors corresponded with marked elevation of serum erythropoietin (EPO). Furthermore, the increase in RBC precursors and EPO production required innate immune signaling mediated by Myd88/TRIF. Neutralization of EPO substantially reduced the immature RBC population in the spleen and allowed a modest increase in host control of infection. These data indicate that early innate immunity to Salmonella initiates marked splenic erythropoiesis and may hinder bacterial clearance. |
| | |
Authors:
|
Amy Jackson; Minelva R Nanton; Hope O'Donnell; Adovi D Akue; Stephen J McSorley |
Related Documents
:
|
678225 - Rodent zoonoses in north queensland: the occurrence and distribution of zoonotic infect... 12656125 - Investigations on the mode and dynamics of transmission and infectivity of borrelia bur... 11476325 - Evidence of ehrlichiosis agents found in ticks (acari: ixodidae) collected from migrato... 17639165 - Extraintestinal focal infections in adults with salmonella enterica serotype choleraesu... 18944235 - Overwintering of frankliniella fusca (thysanoptera: thripidae) on winter annual weeds i... 19052285 - Concurrent infection with heligmosomoides polygyrus modulates murine host response agai... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-15 |
Journal Detail:
|
Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 185 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-04 Completed Date: 2010-12-02 Revised Date: 2013-05-14 |
Medline Journal Info:
|
Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 6198-204 Citation Subset: AIM; IM |
Affiliation:
|
Center for Infectious Diseases and Microbiology Translational Research, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Erythropoiesis / immunology* Erythropoietin / blood Flow Cytometry Immunity, Innate / immunology* Immunoassay Mice Mice, Inbred C57BL Mice, Transgenic Reticulocytes / immunology Salmonella Infections / blood, immunology*, physiopathology Splenomegaly / immunology*, microbiology, parasitology |
| Grant Support | |
ID/Acronym/Agency:
|
AI055743/AI/NIAID NIH HHS; AI076278/AI/NIAID NIH HHS; AI56172/AI/NIAID NIH HHS; P01 AI056172-06A2/AI/NIAID NIH HHS; R01 AI055743/AI/NIAID NIH HHS; R01 AI055743-08/AI/NIAID NIH HHS; R01 AI076278/AI/NIAID NIH HHS; R01 AI076278-01A1/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
11096-26-7/Erythropoietin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Generation and differentiation of IL-17-producing CD4+ T cells in malignant pleural effusion.
Next Document: The rapid induction of HLA-E is essential for the survival of antigen-activated naive CD4 T cells fr...