Document Detail

Inlet protein aggregation: a new mechanism for lubricating film formation with model synovial fluids.
Jump to Full Text
MedLine Citation:
PMID:  21870377     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper reports a fundamental study of lubricant film formation with model synovial fluid components (proteins) and bovine serum (BS). The objective was to investigate the role of proteins in the lubrication process. Film thickness was measured by optical interferometry in a ball-on-disc device (mean speed range of 2-60 mm/s). A commercial cobalt-chromium (CoCrMo) metal femoral head was used as the stationary component. The results for BS showed complex time-dependent behaviour, which was not representative of a simple fluid. After a few minutes sliding BS formed a thin adherent film of 10-20 nm, which was attributed to protein absorbance at the surface. This layer was augmented by a hydrodynamic film, which often increased at slow speeds. At the end of the test deposited surface layers of 20-50 nm were measured. Imaging of the contact showed that at slow speeds an apparent 'phase boundary' formed in the inlet just in front of the Hertzian zone. This was associated with the formation of a reservoir of high-viscosity material that periodically moved through the contact forming a much thicker film. The study shows that proteins play an important role in the film-forming process and current lubrication models do not capture these mechanisms.
Authors:
J Fan; C W Myant; R Underwood; P M Cann; A Hart
Related Documents :
21928787 - Synthesis and morphological study of thick benzyl methacrylate-styrene diblock copolyme...
22197417 - Detection of pb(2+) at attomole levels by using dynamic light scattering and unmodified...
19318277 - In situ sims analysis and reactions of surfaces prepared by soft landing of mass-select...
21830287 - Dual fluorescence self-assembled multilayers bearing a fluorescent internal standard fo...
20681547 - Physico-chemical characteristics of media-milled corn starch.
6719467 - The effects of ethanol ingestion and repeated benzene exposures on benzene pharmacokine...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine     Volume:  225     ISSN:  0954-4119     ISO Abbreviation:  Proc Inst Mech Eng H     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-08-29     Completed Date:  2011-09-20     Revised Date:  2014-08-19    
Medline Journal Info:
Nlm Unique ID:  8908934     Medline TA:  Proc Inst Mech Eng H     Country:  England    
Other Details:
Languages:  eng     Pagination:  696-709     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Albumins / chemistry
Animals
Biomedical Engineering
Cattle
Equipment Failure Analysis
Hip Prosthesis
Humans
Lubrication
Models, Biological
Protein Multimerization
Surface Properties
Synovial Fluid / chemistry*
gamma-Globulins / chemistry
Chemical
Reg. No./Substance:
0/Albumins; 0/gamma-Globulins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Proc Inst Mech Eng H
Journal ID (iso-abbrev): Proc Inst Mech Eng H
Journal ID (publisher-id): PIH
Journal ID (hwp): sppih
ISSN: 0954-4119
ISSN: 2041-3033
Publisher: SAGE Publications, Sage UK: London, England
Article Information
Download PDF
© IMechE 2011
open-access:
Received Day: 1 Month: 2 Year: 2010
Accepted Day: 19 Month: 1 Year: 2011
epub-ppub publication date: Month: 7 Year: 2011
Print publication date: Month: 7 Year: 2011
Volume: 225 Issue: 7
First Page: 696 Last Page: 709
PubMed Id: 21870377
ID: 4107775
DOI: 10.1177/0954411911401306
Publisher Id: 10.1177_0954411911401306

Inlet protein aggregation: a new mechanism for lubricating film formation with model synovial fluids
J Fan1
C W Myant1*
R Underwood2
P M Cann1
A Hart2
1Tribology Group, Department of Mechanical Engineering, Imperial College London, London, UK
2London Retrieval Centre, Charing Cross Hospital, Imperial College London, London, UK
*Tribology Group, Department of Mechanical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, UK. email: connor.myant@imperial.ac.uk

The authors wish to thank the EPSRC for funding this research (EP/E028721/1) and Dr A. Mavraki for carrying out the rheology measurements.


References
1. Medel F. J.,Puértolas J. A.. Wear resistance of highly cross-linked and remelted polyethylenes after ion implantation and accelerated ageing. Proc. IMechE, Part H: J. Engineering in Medicine, Year: 2008, 222(6), 877–885 DOI: 10.1243/09544119JEIM386
2. Hart A. J.,Hester T.,Sinclair K.,Powell J. J.,Goodship A. E.,Pele L.,Fersht N.,Skinner J.. The association between metal ions from hip resurfacing and reduced T-cell counts. J. Bone Joint Surg. Br., Year: 2006, 88(4), 449–45416567777
3. Revell P. A.,Al-Saffar N.,Kobayashi A.. Biological reaction to debris in relation to joint prostheses. Proc. IMechE, Part H: J. Engineering in Medicine, Year: 1997, 211(2), 187–197 DOI: 10.1243/0954411971534304
4. Hills B.. Boundary lubrication in vivo. Proc. IMechE, Part H: J. Engineering in Medicine, Year: 2000, 214(1), 83–94 DOI: 10.1243/0954411001535264
5. Fang H.-W.,Hsieh M.-C.,Huang H.-T.,Tsai C.-Y.,Chang M.-H.. Conformational and adsorptive characteristics of albumin affect interfacial protein boundary lubrication: from experimental to molecular dynamics simulation approaches. Colloids Surf. B Biointerfaces, Year: 2009, 68(2), 171–17719026525
6. Jalali-Vahid D.,Jin Z. M.,Dowson D.. Effect of start-up conditions on elastohydrodynamic lubrication of metal-on-metal hip implants. Proc. IMechE, Part J: J. Engineering Tribology, Year: 2006, 220(3), 143–150 DOI: 10.1243/13506501JET150
7. Cooke A. F.,Dowson D.,Wright V.. The rheology of synovial fluid and some potential synthetic lubricants for degenerate synovial joints. Proc. Instn. Mech. Engrs, J. Engineering in Medicine, Year: 1978, 7(7), 66–72 DOI: 10.1243/EMED_JOUR_1978_007_021_02
8. Kitano T.,Ateshian G. A.,Mow V. C.,Kadoya Y.,Yamano Y.. Constituents and pH changes in protein rich hyaluronan solution affect the biotribological properties of artificial articular joints. J. Biomech., Year: 2001, 34(8), 1031–103711448695
9. McCarty D. J.. Synovial fluid in arthritis and applied conditions. In A textbook of rheumatology (Ed. McCarty D. J.), Year: 1989, pp. 69–90 (Lea and Febiger, Philadelphia, Pennsylvania, USA).
10. Wang A.,Essner A.,Schmidig G.. The effects of lubricant composition on in vitro wear testing of polymeric acetabular components. J. Biomed. Mater. Res. B Appl. Biomater., Year: 2003, 68(1), 45–5214689495
11. Scholes S. C,Unsworth A.,Goldsmith A. A. J.. A frictional study of total hip joint replacements. Phys. Med. Biol., Year: 2000, 45(12), 3721–373511131195
12. Wimmer M. A.,Sprecher C.,Hauert R.,Täger G.,Fischer A.. Tribochemical reaction on metal-on-metal hip joint bearings. A comparison between in-vitro and in-vivo results. Wear, Year: 2003, 255(4), 1007–1014
13. Wang A.,Yue S.,Bobyn J. D.,Chan F. W.,Medley J. B.. Surface characterization of metal-on-metal hip implants tested in a hip simulator. Wear, Year: 1999, 225–229(2), 708–715
14. Cann P. M.,Mavraki A.. Lubricating film thickness measurements with bovine serum. Tribol. Int., Year: 2011, 44(5), 550–556
15. Oates K.,Krause W. E.,Jones R. L.,Colby R. H.. Rheopexy of synovial fluid and protein aggregation. J. R. Soc. Interface, Year: 2006, 3(6), 167–17416849228
16. Johnston G. J.,Wayte R.,Spikes H. A.. The measurement and study of very thin lubricant films in concentrated contacts. Tribol. Trans., Year: 1991, 34(2), 187–194
17. Hooke C. J.. The elastohydrodynamic lubrication of heavily loaded point contacts. Proc. Instn Mech. Engrs, J. Mechanical Engineering Science, Year: 1980, 22, 183–187 DOI: 10.1243/JMES_JOUR_1980_022_036_02
18. Hurley S.,Cann P.. IR spectroscopic analysis of grease lubricant films in rolling contacts. In Lubrication at the Frontier - The Role of the Interface and Surface Layers in the Thin Film and Boundary Regime, Proceedings of the 25th Leeds-Lyon Symposium on TribologyYear: 1999, 36, 589–600 DOI:10.1016/S0167-8922(99)80079-0
19. Pradier C. M.,Karman F.,Telegdi J.,Kalman E.,Marcus P.. Adsorption of bovine serum albumin on chromium and molybdenum surfaces investigated by Fourier-transform infrared reflection–absorption spectroscopy (FT-IRRAS) and X-ray photoelectron spectroscopy. J. Phys. Chem. B, Year: 2003, 107, 6766–6773
20. London Implant Retrieval Centre. Leading research in metal-on-metal hip implant failures, 2010, available from http://www1.imperial.ac.uk/surgeryandcancer/divisionofsurgery/clinical_themes/musculo/retrieval/. (access date 23 November 2010).
21. Fitzpatrick H.,Luckham P. F.,Eriksen S.,Hammod K.. Bovine serum albumin adsorption to mica surfaces. Colloids Surf., Year: 1992, 65(1), 43–49
22. Santos O.,Nylander T.,Paulsson M.,Trägårdh C.. Whey protein adsorption onto steel surfaces – effect of temperature, flow rate, residence time and aggregation. J. Food Engng, Year: 2006, 74(4), 468–483
23. Najbar L. V.,Considine R. F.,Drummond C. J.. Heat-induced aggregation of a globular egg-white protein in aqueous solution: investigation by atomic force microscope imaging and surface force mapping modalities. Langmuir, Year: 2003, 19(7), 2880–2887
24. Mori O.,Imae T.. AFM investigation of the adsorption process of bovine serum albumin on mica. Colloids Surf. B Biointerfaces, Year: 1997, 9(1–2), 31–36
25. Band T. J.. Materials and metallurgy. In Modern hip resurfacing (Ed. McMinn D.), Year: 2009, pp. 43–63 (Springer).
27. Schmid C. F.,Klingenberg D. J.. Mechanical flocculation in flowing fibre suspensions. Phys. Rev. Lett., Year: 2000, 84(22), 290–29311015893
26. Lu Z.,McKellop H.. Frictional heating of bearing materials tested in a lubricant in a hip joint wear simulator. Proc. MechE, Part H: J. Engineering in Medicine, Year: 1997, 211(1), 101–107 DOI: 10.1243/0954411971534728
28. Varano R.,Bobyn J. D.,Medley J. B.,Yue S.. The effect of microstructure on the wear of cobalt-based alloys used in metal-on-metal hip implants. Proc. IMechE, Part H: J. Engineering in Medicine, Year: 2006, 220(2), 145–159 DOI: 10.1243/09544119JEIM110

Article Categories:
  • Article

Keywords: artificial hip joint, synovial fluid, boundary lubrication, CoCrMo alloy.

Previous Document:  Pressure waves in the aorta during isolated abdominal belt loading: the magnitude, phasing, and atte...
Next Document:  Salvage procedures for trochanteric femoral fractures after internal fixation failure: biomechanical...