| Ink dispersion by sequential contractions in isolated segments of guinea pig ileum and duodenum. | |
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MedLine Citation:
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PMID: 19019034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Conventional preparations that record the effect of contractions on intestinal flow assess primarily net propulsion and not flow events that like mixing are essential for digestion and absorption. Here we recorded the flow of an ink bolus in response to peristaltic contractions of segments of guinea pig intestine. It took three to four contraction/relaxation cycles to disperse a tiny and compact ink bolus throughout the intestinal segment. This was achieved by stretching, propulsion and separation of the bolus into portions during the contraction phase, and return and confluence of the bolus portions during the relaxation phase. As the contraction advanced through the intestinal segment, it generated rapid retrograde flow through its narrow lumen; eddies (flow vortices) formed at upstream shoulder of the contracting segment and dispersed the ink radially. The contraction cleared much of the fluid from the intestinal segment; during the subsequent relaxation, fluid returned into the segment, and carried portions of the ink upstream into the segment where it coalesced with residual portions. The current video observations of luminal flow confirm earlier predictions on luminal flow derived from computations. These flow events are likely an important mechanism through which intestinal contractions promote digestion and absorption. |
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Authors:
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K S Schulze; E Clark |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 20 ISSN: 1365-2982 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-21 Completed Date: 2009-03-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 1317-27 Citation Subset: IM |
Affiliation:
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Gastroenterology Research, VAMC, Iowa City, IA, USA. konrad-schulze@uiowa.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Digestion / physiology* Duodenum / physiology* Female Guinea Pigs Ileum / physiology* Ink Male Organ Culture Techniques Peristalsis / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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