Document Detail


Injury switches melatonin production source from endocrine (pineal) to paracrine (phagocytes) - melatonin in human colostrum and colostrum phagocytes.
MedLine Citation:
PMID:  16879319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A large number of data show that melatonin has immunomodulatory properties and is produced by immunocompetent cells; also, some evidence suggests a 'feedback' of the activated immune system on the pineal gland. In this paper, we studied immune-pineal interactions in colostrum obtained from healthy puerperae and mothers with mastitis taking into account that, (a) melatonin levels in milk reflects pineal activity and (b) colostrum quiescent mononuclear and polymorphonuclear phagocytes from healthy mothers in culture are adequate for evaluating the ability of immunocompetent cells to produce melatonin. Here we compared the diurnal and nocturnal melatonin levels in colostrum from healthy puerperae and mothers with mastitis; this is a unique noninvasive model for determining pineal activity in the proinflammatory phase of a defense response. In addition, we determined the 'in vitro' production of melatonin by colostrum immunocompetent cells stimulated by enteropathogenic Escherichia coli or zymosan. Suppression of nocturnal melatonin rise in mothers with mastitis was highly correlated with increased tumor necrosis factor-alpha (TNF-alpha) secretion. This result, interpreted taking into account the presence of the transcription factor nuclear factor kappa B in pineal gland, suggest that the proinflammatory cytokine can inhibit nocturnal pineal melatonin production. On the other hand, stimulated, but not quiescent, immunocompetent cells secreted in the colostrum produced melatonin in vitro. In addition, this production ceases after bacteria killing. These results suggest that during the response to an injury the production of melatonin can be transiently shifted from an endocrine (pineal) to a paracrine (immunocompetent cells) source.
Authors:
Gerlândia N Pontes; Elaine C Cardoso; Magda M S Carneiro-Sampaio; Regina P Markus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pineal research     Volume:  41     ISSN:  0742-3098     ISO Abbreviation:  J. Pineal Res.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-01     Completed Date:  2006-09-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8504412     Medline TA:  J Pineal Res     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  136-41     Citation Subset:  IM    
Affiliation:
Laboratory of Chronopharmacology, Department of Physiology, Institute of Bioscience, Universidade de Sao Paulo, Sao Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Colostrum / chemistry*,  immunology
Escherichia coli / immunology
Female
Humans
Infant
Mastitis / immunology,  metabolism*
Melatonin / analysis,  biosynthesis*
Paracrine Communication*
Phagocytes / immunology,  metabolism*
Pineal Gland / metabolism*
Postpartum Period
Pregnancy
Tumor Necrosis Factor-alpha / analysis
Zymosan / immunology
Chemical
Reg. No./Substance:
0/Tumor Necrosis Factor-alpha; 73-31-4/Melatonin; 9010-72-4/Zymosan

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