Document Detail

Injury-induced CRMP4 expression in adult sensory neurons; a possible target gene for ciliary neurotrophic factor.
MedLine Citation:
PMID:  20800647     Owner:  NLM     Status:  MEDLINE    
Neurotrophic cytokines, such as ciliary neurotrophic factor (CNTF) play an important role in the development and regeneration of the nervous system. In the present study, we screened gene expression induced by CNTF in adult dorsal root ganglion (DRG) neurons using the Illumina microarray. We found that the expression of both short and long forms of collapsin response-mediator protein 4 (CRMP4) was increased in cultured primary sensory neurons by CNTF. In addition, sciatic nerve injury induced the expression of CRMP4 mRNA and protein in DRG neurons. Finally, the increased CRMP4 protein was transported into peripheral axons following nerve injury. These findings indicate that CRMP4 may be a target gene for CNTF in the regenerative axon growth of DRG neurons after injury.
So Young Jang; Yoon Kyung Shin; Junyang Jung; Sang Hwa Lee; Su-Yeong Seo; Duk Joon Suh; Hwan Tae Park
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-26
Journal Detail:
Title:  Neuroscience letters     Volume:  485     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Department of Physiology, Mitochondria Hub Regulation Center, College of Medicine, Dong-A University, South Korea.
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MeSH Terms
Axons / metabolism
Cells, Cultured
Ciliary Neurotrophic Factor / pharmacology,  physiology*
Ganglia, Spinal / cytology,  metabolism*
Gene Expression Profiling
Nerve Tissue Proteins / biosynthesis*,  genetics
Oligonucleotide Array Sequence Analysis
Protein Transport
RNA, Messenger / biosynthesis
Rats, Sprague-Dawley
Sciatic Nerve / injuries,  metabolism
Sensory Receptor Cells / metabolism*
Reg. No./Substance:
0/Ciliary Neurotrophic Factor; 0/Crmp4 protein, rat; 0/Nerve Tissue Proteins; 0/RNA, Messenger

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