Document Detail

Injury is a major inducer of epidermal innate immune responses during wound healing.
MedLine Citation:
PMID:  19727116     Owner:  NLM     Status:  MEDLINE    
We examined the importance of injury for the epidermal innate immune response in human skin wounds. We found that injury, independent of infiltrating inflammatory cells, generated prominent chemotactic activity toward neutrophils in injured skin because of IL-8 production. Furthermore, injury was a major inducer of the expression of antimicrobial (poly)peptides (AMPs) in skin wounds. In human skin, these injury-induced innate immune responses were mediated by activation of the epidermal growth factor receptor (EGFR). Consequently, inhibition of the EGFR blocked both the chemotactic activity generated in injured skin and the expression of the majority of the AMPs. The importance of injury was confirmed in mouse experiments in vivo, in which injury independent of infection was a potent inducer of AMPs in skin wounds. To our knowledge, these data thereby provide a previously unreported molecular link between injury and neutrophil accumulation and identify the molecular background for the vast expression of IL-8 and AMPs in wounded epidermis. Conceptually, these data show that the growth factor response elicited by injury is important for the recruitment of neutrophils in skin wounds.
K Markus Roup?; Mads Nybo; Ulf Sj?bring; Per Alberius; Artur Schmidtchen; Ole E S?rensen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-03
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  130     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-16     Completed Date:  2010-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1167-77     Citation Subset:  IM    
Division of Infection Medicine, Lund University, Lund, Sweden.
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MeSH Terms
Adenosine Monophosphate / metabolism
Cells, Cultured
Chemotaxis / immunology
Epidermis / immunology*,  injuries*,  microbiology
Interleukin-8 / metabolism
Interleukins / metabolism
Keratinocytes / cytology,  immunology*
Mice, Inbred C57BL
Neutrophils / immunology*,  metabolism
Organ Culture Techniques
Receptor, Epidermal Growth Factor / metabolism
Species Specificity
Streptococcal Infections / immunology,  metabolism
Streptococcus pyogenes
Wound Healing / immunology*
Reg. No./Substance:
0/Interleukin-8; 0/Interleukins; 0/interleukin 20; 0/interleukin-24; 61-19-8/Adenosine Monophosphate; EC, Epidermal Growth Factor
Comment In:
J Invest Dermatol. 2010 Apr;130(4):929-32   [PMID:  20231833 ]
Erratum In:
J Invest Dermatol. 2010 Mar;130(3):910

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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