Document Detail

Injury-induced neurogenesis: consideration of resident microglia as supportive of neural progenitor cells.
MedLine Citation:
PMID:  20524106     Owner:  NLM     Status:  MEDLINE    
The induction of neurogenesis in the adult subgranular zone (SGZ) by injury is often accompanied by changes in the extracellular environment that can have significant impacts on neural progenitor cells (NPCs). We examined the induction of neurogenesis in the SGZ at 72 h following an injection of the hippocampal toxicant, trimethyltin (TMT; 2 mg/kg, ip) inducing apoptosis in dentate granule neurons. BrdU+ incorporation during the active period of neuronal death indicated NPC proliferation and migration of newly generated cells into the granule cell layer (GCL). BrdU+ cells were transiently in contact with process bearing microglia within the inner SGZ layer. Contact with GFAP+ astrocyte processes occurred once cells were within the GCL. A small percentage of the BrdU+ cells within the SGZ region showed immunoreactivity for tumor necrosis factor (TNF) p75 receptor (TNFp75R). In mice deficient for TNFp75R, TMT injection produced an equivalent level of dentate granule cell death however; BrdU+ cells were localized at the SGZ as compared to the presence of cells within the GCL in the WT mice dosed with TMT. These data suggest that cells generated by NPCs in the SGZ induced with a focal lesion to the dentate granule neurons of adolescent mice maintain the capacity to utilize the neuroinflammation and microglia responses within their environment for migration into the GCL.
Christopher A McPherson; Andrew D Kraft; G Jean Harry
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Intramural     Date:  2010-06-04
Journal Detail:
Title:  Neurotoxicity research     Volume:  19     ISSN:  1476-3524     ISO Abbreviation:  Neurotox Res     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2010-12-30     Completed Date:  2011-11-09     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  100929017     Medline TA:  Neurotox Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  341-52     Citation Subset:  IM    
Neurotoxicology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Science, National Institutes of Health, MD C1-04, P.O. Box 12233, Research Triangle Park, NC 27709, USA.
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MeSH Terms
Apoptosis / physiology
Cell Movement / physiology
Hippocampus / injuries*,  pathology*,  physiology
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Microglia / pathology*,  physiology
Microscopy, Fluorescence
Neurogenesis* / physiology
Neurons / pathology*,  physiology
Stem Cells / pathology*,  physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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