| Injury-induced neurogenesis: consideration of resident microglia as supportive of neural progenitor cells. | |
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MedLine Citation:
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PMID: 20524106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The induction of neurogenesis in the adult subgranular zone (SGZ) by injury is often accompanied by changes in the extracellular environment that can have significant impacts on neural progenitor cells (NPCs). We examined the induction of neurogenesis in the SGZ at 72 h following an injection of the hippocampal toxicant, trimethyltin (TMT; 2 mg/kg, ip) inducing apoptosis in dentate granule neurons. BrdU+ incorporation during the active period of neuronal death indicated NPC proliferation and migration of newly generated cells into the granule cell layer (GCL). BrdU+ cells were transiently in contact with process bearing microglia within the inner SGZ layer. Contact with GFAP+ astrocyte processes occurred once cells were within the GCL. A small percentage of the BrdU+ cells within the SGZ region showed immunoreactivity for tumor necrosis factor (TNF) p75 receptor (TNFp75R). In mice deficient for TNFp75R, TMT injection produced an equivalent level of dentate granule cell death however; BrdU+ cells were localized at the SGZ as compared to the presence of cells within the GCL in the WT mice dosed with TMT. These data suggest that cells generated by NPCs in the SGZ induced with a focal lesion to the dentate granule neurons of adolescent mice maintain the capacity to utilize the neuroinflammation and microglia responses within their environment for migration into the GCL. |
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Authors:
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Christopher A McPherson; Andrew D Kraft; G Jean Harry |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Intramural Date: 2010-06-04 |
Journal Detail:
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Title: Neurotoxicity research Volume: 19 ISSN: 1476-3524 ISO Abbreviation: Neurotox Res Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2010-12-30 Completed Date: 2011-11-09 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 100929017 Medline TA: Neurotox Res Country: United States |
Other Details:
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Languages: eng Pagination: 341-52 Citation Subset: IM |
Affiliation:
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Neurotoxicology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Science, National Institutes of Health, MD C1-04, P.O. Box 12233, Research Triangle Park, NC 27709, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology Cell Movement / physiology Hippocampus / injuries*, pathology*, physiology Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Microglia / pathology*, physiology Microscopy, Fluorescence Neurogenesis* / physiology Neurons / pathology*, physiology Stem Cells / pathology*, physiology |
| Grant Support | |
ID/Acronym/Agency:
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ZIA ES021164-13/ES/NIEHS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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