Document Detail

Injurious ventilation strategies cause systemic release of IL-6 and MIP-2 in rats in vivo.
MedLine Citation:
PMID:  14617266     Owner:  NLM     Status:  MEDLINE    
In vivo experiments showed no increased production of tumour necrosis factor (TNF) in response to injurious ventilation strategies in otherwise untreated animals. Because interleukin-6 (IL-6) and macrophage inflammatory protein-2 (MIP-2) are more sensitive markers of ventilation-induced cytokine release, serum and bronchoalveolar lavage (BAL) samples were examined for these mediators. Eighty-five adult rats were randomized to three different ventilation strategies. Rats were ventilated with low pressures and low tidal volumes [13/3; peak inspiratory pressure (PIP)/positive end-expiratory pressure (PEEP) in cmH2O], the second group of rats was ventilated with high pressures and low PEEP resulting in high tidal volumes (32/6), and the third group was ventilated with the same high pressures but without PEEP (32/0). Animals were ventilated either for 90 or 240 min, subsequently serum and BAL were collected for analyses on IL-6 and MIP-2 content. Non-ventilated animals served as healthy controls. Ventilation with 32/0 for 90 or 240 min, led to increased serum IL-6 levels. Serum MIP-2 levels were increased by ventilation with 32/6 (90 min) and 32/0 (240 min). Ventilation under any condition, even at 13/3, resulted in elevated MIP-2 levels in the BAL fluid. Even at normal pressures pulmonary MIP-2 levels were increased, suggesting that ventilation may promote pro-inflammatory responses in healthy subjects.
Jack J Haitsma; Stefan Uhlig; Serge J Verbrugge; Rolf Göggel; Davey L H Poelma; Burkhard Lachmann
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  23     ISSN:  1475-0961     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-17     Completed Date:  2004-07-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  349-53     Citation Subset:  IM    
Department of Anesthesiology, Erasmus MC-Faculty, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
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MeSH Terms
Bronchoalveolar Lavage Fluid / chemistry*
Chemokine CXCL2
Chemokines, CXC / analysis,  blood
Intercellular Signaling Peptides and Proteins / analysis,  blood
Interleukin-6 / analysis*,  blood
Rats, Sprague-Dawley
Respiration, Artificial / adverse effects*
Respiratory Distress Syndrome, Adult / blood*,  etiology*,  immunology
Reg. No./Substance:
0/Chemokine CXCL2; 0/Chemokines, CXC; 0/Cxcl2 protein, rat; 0/Intercellular Signaling Peptides and Proteins; 0/Interleukin-6

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