| Injured mice at the gym: review, results and considerations for combining chondroitinase and locomotor exercise to enhance recovery after spinal cord injury. | |
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MedLine Citation:
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PMID: 20558254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise provides a number of important benefits after spinal cord injury in clinical studies and animal models. However, the amount of functional improvement in overground locomotion obtained with exercise alone has been limited thus far, for reasons that are still poorly understood. One hypothesis is that the complex network of endogenous extracellular matrix components, including chondroitin sulfate proteoglycans (CSPGs), can inhibit exercise-induced remodeling and limit plasticity of spared circuitry in the adult central nervous system. Recent animal studies have shown that chondroitinase ABC (ChABC) can enhance plasticity in the adult nervous system by cleaving glycosaminoglycan sidechains from CSPGs. In this article we review the current literature on plasticity observed with locomotor training and following degradation of CSPGs with ChABC and then present a rationale for the use of exercise combined with ChABC to promote functional recovery after spinal cord injury. We also present results of a preliminary study that tested the simplest approach for combining these treatments; use of a single intraparenchymal injection of ChABC administered to the lumbar enlargement of mice with voluntary wheel running exercise after a mid-thoracic spinal contusion injury. The results are negative, yet serve to highlight limitations in our understanding of the most effective protocols for combining these approaches. Further work is directed to identify the timing, type, and quantity of exercise and pharmacological interventions that can be used to maximize functional improvements by strengthening appropriate synaptic connections. |
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Authors:
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Lyn B Jakeman; Emily L Hoschouer; D Michele Basso |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-06-15 |
Journal Detail:
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Title: Brain research bulletin Volume: 84 ISSN: 1873-2747 ISO Abbreviation: Brain Res. Bull. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-24 Completed Date: 2011-05-31 Revised Date: 2012-03-12 |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: United States |
Other Details:
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Languages: eng Pagination: 317-26 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Physiology and Cell Biology, The Ohio State University Medical Center, Columbus, 43210, USA. jakeman.1@osu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chondroitin ABC Lyase / pharmacology*, therapeutic use* Exercise Humans Mice Motor Activity / physiology* Nerve Regeneration / drug effects*, physiology Neuronal Plasticity / drug effects Spinal Cord Injuries / rehabilitation*, therapy* |
| Grant Support | |
ID/Acronym/Agency:
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NS043246/NS/NINDS NIH HHS; NS045758/NS/NINDS NIH HHS; R01 NS043246-05/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 4.2.2.20/Chondroitin ABC Lyase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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