Document Detail


Injections of muscimol into the paraventricular thalamic nucleus, but not mediodorsal thalamic nuclei, induce feeding in rats.
MedLine Citation:
PMID:  23111346     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The paraventricular thalamic nucleus (PVT) is a component of the midline thalamic group that is interconnected with several brain regions known to play important roles in the control of food intake, including the lateral hypothalamus and nucleus accumbens shell, suggesting that the PVT itself may be involved in mediating feeding behavior. In the current study, we examined whether inhibition of cells in the PVT with the GABA(A) agonist muscimol could alter food intake in non-deprived rats. To control for possible spread of the drug, we also observed food intake after injections of muscimol into the overlying ventricle or laterally adjacent mediodorsal thalamic nuclei (MD). We found that muscimol injections into the central PVT dose-dependently increased food intake. In contrast, intra-MD injections of muscimol resulted in a potent dose-dependent suppression of food intake, while those into the overlying ventricle had no effect. These results support the proposal that the PVT is a component of the neural circuitry controlling feeding behavior.
Authors:
Thomas R Stratford; David Wirtshafter
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-10-27
Journal Detail:
Title:  Brain research     Volume:  1490     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-24     Completed Date:  2013-05-29     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  128-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Eating / drug effects
Feeding Behavior / drug effects*
GABA-A Receptor Agonists / administration & dosage,  pharmacology*
Injections, Intraventricular
Male
Mediodorsal Thalamic Nucleus / physiology*
Microinjections
Muscimol / administration & dosage,  pharmacology*
Paraventricular Hypothalamic Nucleus / physiology*
Rats
Rats, Sprague-Dawley
Satiation / physiology
Third Ventricle
Grant Support
ID/Acronym/Agency:
R01 DK071738/DK/NIDDK NIH HHS; R01DK071738/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/GABA-A Receptor Agonists; 2763-96-4/Muscimol
Comments/Corrections

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