Document Detail

Injection of synthetic human growth hormone-releasing factors in dairy cows. 1. Effect on feed intake and milk yield and composition.
MedLine Citation:
PMID:  2896206     Owner:  NLM     Status:  MEDLINE    
Eighteen multiparous Holstein cows in the second half of their lactation were used to determine the effect of human growth hormone-releasing factor (1-44)NH2 and a fragment of growth hormone-releasing factor (1-29)NH2 on lactational performance and feed intake. Saline, the 44-amino acid peptide or the 29-amino acid fragment, at the same dose per injection (.2 was injected intravenously at 4-h intervals for 10 d. Average milk yield, milk composition, feed intake, and feed efficiency were compared for the second half of each 10-d preinjection, injection, and post-injection period. Injections of the 44-amino acid peptide and the 29-amino acid fragment increased milk yield 18.6 and 14.6%, respectively. Feed intake was not changed, but feed efficiency was increased 23.9 and 18.8% over control following 44-amino acid peptide and the 29-amino acid fragment injection, respectively. The lactational response was not different between the two peptides for any of the variables measured. This study demonstrates the feasibility of using a growth hormone-releasing factor fragment as an alternative method of elevating milk yield in cattle via somatotropins.
G Pelletier; D Petitclerc; H Lapierre; M Bernier-Cardou; J Morisset; P Gaudreau; Y Couture; P Brazeau
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of dairy science     Volume:  70     ISSN:  0022-0302     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-06-02     Completed Date:  1988-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2511-7     Citation Subset:  IM    
Agriculture Canada Research Station, Lennoxville, Québec.
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MeSH Terms
Cattle / physiology*
Eating / drug effects*
Growth Hormone-Releasing Hormone / administration & dosage,  analogs & derivatives*,  pharmacology
Injections, Intravenous
Lactation / drug effects*
Milk / analysis*
Peptide Fragments / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Peptide Fragments; 0/somatotropin releasing hormone (1-44)amide; 86168-78-7/Sermorelin; 9034-39-3/Growth Hormone-Releasing Hormone

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