| Injection molded microfluidic chips featuring integrated interconnects. | |
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MedLine Citation:
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PMID: 17102848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An injection molding process for the fabrication of disposable plastic microfluidic chips with a cycle time of 2 min has been designed, developed, and implemented. Of the sixteen commercially available grades of cyclo-olefin copolymer (COC) that were screened for autofluorescence and transparency to ultraviolet (UV) light, Topas 8007 x 10 was identified as the most suitable for production. A robust solid metal mold insert defining the microfluidic channels was rapidly microfabricated using a process that significantly reduces the time required for electroplating. No wear of the insert was observed even after over 1000 cycles. The chips were bonded by thermal fusion using different bonding conditions. Each condition was tested and its suitability evaluated by burst pressure measurements. The COC microfluidic chips feature novel, integrated, reversible, standardized, ready-to-use interconnects that enable operation at pressures up to 15.6 MPa, the highest value reported to date. The suitability of these UV transparent, high pressure-resistant, disposable devices was demonstrated by in situ preparation of a high surface area porous polymer monolith within the channels. |
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Authors:
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Dieudonne A Mair; Emil Geiger; Albert P Pisano; Jean M J Fréchet; Frantisek Svec |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2006-07-31 |
Journal Detail:
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Title: Lab on a chip Volume: 6 ISSN: 1473-0197 ISO Abbreviation: Lab Chip Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-11-14 Completed Date: 2007-05-09 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 101128948 Medline TA: Lab Chip Country: England |
Other Details:
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Languages: eng Pagination: 1346-54 Citation Subset: IM |
Affiliation:
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Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Microfluidic Analytical Techniques* Microinjections* Polymers Porosity Pressure |
| Grant Support | |
ID/Acronym/Agency:
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GM-48364/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Polymers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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