Document Detail

Injection of botulinum toxin type A in the urethral sphincter to treat lower urinary tract dysfunction: review of indications, techniques and results: 2011 update.
MedLine Citation:
PMID:  21854710     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: The first application of botulinum toxin type A (BoNT-A) in urology was its injection into the urinary sphincter to treat neurogenic detrusor-sphincter dyssynergia (DSD) in quadriplegic men. Since that first report by Dyskatra et al in 1988, the results of focal BTA injections into the sphincter, the bladder wall and lately into the prostate have raised the interest of the urology community in this promising new therapeutic modality. This is an evidence-based review of the current indications, techniques and outcomes of BTA injections into the urethral sphincter.
MATERIALS AND METHODS: The Medline database was searched for the period between 1966 and October 2010, using the keywords 'botulinum toxin' and 'urethra' or 'urethral sphincter'. English written articles ere selected. A level of evidence according to the Oxford Centre for evidence-based medicine was assigned to each article.
CONCLUSION: Since our first review in 2006, very little has been added to the literature on the use of botulinum toxin injected into the external sphincter. At present, those most likely to benefit from intrasphincteric BTA injection are MS patients suffering the symptoms of DSD and quadriplegic men with DSD unable to perform self-catheterization. Well developed and conducted studies are necessary; these must be done urgently to better define the place and the results of this drug otherwise widely used in other indications in urology.
Wally Mahfouz; Gilles Karsenty; Jacques Corcos
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Canadian journal of urology     Volume:  18     ISSN:  1195-9479     ISO Abbreviation:  Can J Urol     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9515842     Medline TA:  Can J Urol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  5787-95     Citation Subset:  IM    
Department of Urology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
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