| Injecting skin fibroblasts into muscles to express human clotting factor IX cDNA. | |
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MedLine Citation:
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PMID: 18726198 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Primary rabbit skin fibroblasts (RSF) containing lacZ reporter gene or human clotting factor IX (hFIX) cDNA could long-termly exist and be expressed after being implanted in rabbit muscles. Among them, the beta-glactosidase expression lasted at least 3 months, and hFIX expression lasted 1 month. These results will be helpful to organically combine the advantages of both skin fibroblasts and muscle, and provide a new way for somatic gene therapy of hemophilia B and other genetic diseases. |
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Authors:
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H Wang; X Yang; Y Xing; D Lu; X Qiu; J Xue |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Science in China. Series C, Life sciences / Chinese Academy of Sciences Volume: 41 ISSN: 1006-9305 ISO Abbreviation: Sci. China, C, Life Sci. Publication Date: 1998 Apr |
Date Detail:
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Created Date: 2008-08-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9611809 Medline TA: Sci China C Life Sci Country: China |
Other Details:
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Languages: eng Pagination: 146-50 Citation Subset: - |
Affiliation:
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Institute of Genetics, Fudan University, 200433, Shanghai, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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