| Injectable poly-L-lactic acid for cosmetic enhancement: learning from the European experience. | |
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MedLine Citation:
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PMID: 19615539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Currently a diverse range of injectable agents are used for noninvasive facial enhancement. Injectable poly-L-lactic acid (PLLA) is a biocompatible, biodegradable, synthetic polymer that is approved for correction of HIV-related facial lipoatrophy in Europe, Canada, and the United States. PLLA is also approved in several countries for cosmetic purposes, and is under review in the United States for this indication. After injection, PLLA elicits a gradual increase in facial volume via hypothesized endogenous production of fibroblasts and, subsequently, collagen, enabling global facial rejuvenation to be tailored, as required, over time. Substantial increases in dermal thickness after injection of PLLA have been observed to last for up to 2 years. This article reviews the use of PLLA in Europe and the United States with regard to practitioner experiences and techniques for optimizing outcomes. Correct reconstitution and administration of PLLA have been found to be important parameters for optimal use of this agent. |
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Authors:
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Kimberly Butterwick; Nicholas J Lowe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: 61 ISSN: 1097-6787 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-20 Completed Date: 2009-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 281-93 Citation Subset: IM |
Affiliation:
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Dermatology/Cosmetic Laser Associates of La Jolla Inc, La Jolla, California 92037, USA. kbutterwick@spa-md.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cosmetic Techniques* Esthetics Europe Female Humans Injections, Intradermal Lactic Acid / therapeutic use* Male Patient Satisfaction Polymers / therapeutic use* Rejuvenation Risk Assessment Skin Aging / drug effects* Treatment Outcome United States |
| Chemical | |
Reg. No./Substance:
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0/Polymers; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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