Document Detail

Injectable form of cross-linked hyaluronan is effective for middle ear wound healing.
MedLine Citation:
PMID:  17926589     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Two studies were designed to investigate a hyaluronan (HA) gel for middle ear (ME) wound healing. METHODS: We used a guinea pig model of ME wound healing. In a long-term study, we performed a comparison of hearing and ME inflammation in 3 groups. Group 1 (n = 8) underwent bilateral wounding of ME mucosa and unilateral packing of the ME with HA gel (Sepragel). Group 2 (n = 6) was the same as group 1 except that the packing was absorbable bovine collagen sponges (Gelfoam). Group 3, the control group (n = 14), had operated, unpacked ears. In a short-term study, we investigated ME retention of HA gel at 1 and 2 weeks (n = 16). RESULTS: At 1 week, all ears showed decreased distortion product otoacoustic emissions (DPOAEs) and auditory brain stem responses (ABRs) secondary to ME packing and postsurgical inflammation. The controls recovered preoperative DPOAEs and ABRs by week 2. Group 1 had decreased low-frequency DPOAEs at weeks 2 and 6, but their high-frequency DPOAEs and ABRs recovered to preoperative values by week 6. Group 2 had hearing losses that persisted throughout the study. Group 1 showed normal ME and inner ear histologic characteristics. Group 2 showed inflammatory cells within the ME and cochleas. Group 1 showed less packing retention than did group 2 at week 6 (p = .016). Eighty-five percent of the HA packing remained at 1 week, and 73% at 2 weeks. CONCLUSIONS: Hyaluronan gel was a relatively safe and effective ME packing material in our animal model.
Simon Angeli; Sarah Connell; Brian Gibson; Ali Ozdek; John T McElveen; Thomas R Van De Water
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Annals of otology, rhinology, and laryngology     Volume:  116     ISSN:  0003-4894     ISO Abbreviation:  Ann. Otol. Rhinol. Laryngol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-10-10     Completed Date:  2007-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0407300     Medline TA:  Ann Otol Rhinol Laryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  667-73     Citation Subset:  AIM; IM    
University of Miami Ear Institute, University of Miami Miller School of Medicine, Miami, FL 33136-1015, USA.
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MeSH Terms
Adjuvants, Immunologic / administration & dosage*
Auditory Threshold / physiology
Cross-Linking Reagents
Disease Models, Animal
Ear, Middle / injuries*
Follow-Up Studies
Guinea Pigs
Hyaluronic Acid / administration & dosage*
Time Factors
Treatment Outcome
Wound Healing / drug effects*
Wounds and Injuries / drug therapy*,  pathology,  physiopathology
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Cross-Linking Reagents; 0/Gels; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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