Document Detail

Injectable collagen in laryngeal rehabilitation.
MedLine Citation:
PMID:  6708694     Owner:  NLM     Status:  MEDLINE    
Glottic insufficiency has been successfully managed by Teflon augmentation of paretic vocal cords over the past two decades. Collagen fulfills the criteria for a suitable bioimplant and is an attractive alternative as it is a normal constituent of the extracellular protein matrix. This study explores the use of modified bovine collagen injected into the canine larynx. Clinical situations are simulated by creating lesions and injecting collagen at different sites. The technique permits precise placement and quantification. Histologic study of the collagen implant fails to show evidence of significant foreign body reaction. The injected collagen appears similar to viable connective tissue and is colonized by host fibroblasts and nourishing capillaries.
C N Ford; D W Martin; T F Warner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Laryngoscope     Volume:  94     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-05-15     Completed Date:  1984-05-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  513-8     Citation Subset:  IM    
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MeSH Terms
Collagen / administration & dosage*
Laryngeal Mucosa / pathology
Laryngeal Muscles / pathology
Prostheses and Implants*
Vocal Cord Paralysis / etiology,  pathology,  rehabilitation*
Reg. No./Substance:

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