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An injectable oxidated hyaluronic acid/adipic Acid dihydrazide hydrogel as a vitreous substitute.
MedLine Citation:
PMID:  20843434     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Vitrectomy is a common procedure for treating ocular-related diseases. The surgery involves removing the vitreous humor from the center of the eye, and vitreous substitutes are needed to replace the vitreous humor after vitrectomy. In the present study, we developed a colorless, transparent and injectable hydrogel with appropriate refractive index as a vitreous substitute. The hydrogel is formed by oxidated hyaluronic acid (oxi-HA) cross-linked with adipic acid dihydrazide (ADH). Hyaluronic acid (HA) was oxidized by sodium periodate to create aldehyde functional groups, which could be cross-linked by ADH. The refractive index of this hydrogel ranged between 1.3420 and 1.3442, which is quite similar to human vitreous humor (1.3345). The degradation tests demonstrated that the hydrogel could maintain the gel matrix over 35 days, depending on the ADH concentration. In addition, the cytotoxicity was evaluated on retina pigmented epithelium (RPE) cells cultivated following the ISO standard (tests for in vitro cytotoxicity), and the hydrogel was found to be non-toxic. In a preliminary animal study, the oxi-HA/ADH hydrogel was injected into the vitreous cavity of rabbit eyes. The evaluations of slit-lamp observation, intraocular pressure, cornea thickness and histological examination showed no significant abnormal biological reactions for 3 weeks. This study suggests that the injectable oxi-HA/ADH hydrogel should be a potential vitreous substitute.
Authors:
Wen-Yu Su; Ko-Hua Chen; Yu-Chun Chen; Yen-Hsien Lee; Ching-Li Tseng; Feng-Huei Lin
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Publication Detail:
Type:  Journal Article     Date:  2010-09-14
Journal Detail:
Title:  Journal of biomaterials science. Polymer edition     Volume:  22     ISSN:  1568-5624     ISO Abbreviation:  J Biomater Sci Polym Ed     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007393     Medline TA:  J Biomater Sci Polym Ed     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1777-97     Citation Subset:  IM    
Affiliation:
Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, R.O.C.; Division of Medical Engineering Research, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, R.O.C.
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