Document Detail

Initiator constitutive mutation with an 'up-promoter' effect in Aspergillus nidulans.
MedLine Citation:
PMID:  1089904     Owner:  NLM     Status:  MEDLINE    
A mutation leading to strong constitutivity for a uric acid-xanthine permease in the lower eukaryote Aspergillus nidulans has been found to be tightly linked to the putative structural gene whose expression it controls in the cis configuration. In addition, it increases the maximal induced level of transport 2.5-fold. This is the first demonstration of an initiator or promoter mutation in an eukaryote.
H N Arst; C Scazzocchio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature     Volume:  254     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-05-10     Completed Date:  1975-05-10     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  31-4     Citation Subset:  IM    
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MeSH Terms
Ammonia / pharmacology
Aspergillus nidulans / enzymology*
Enzyme Induction
Enzyme Repression
Genes, Dominant
Membrane Transport Proteins / biosynthesis*
Uric Acid
Reg. No./Substance:
0/Membrane Transport Proteins; 0/Xanthines; 69-93-2/Uric Acid; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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