Document Detail

Initiation of wound healing by proteinases released from damaged cells.
MedLine Citation:
PMID:  1806547     Owner:  NLM     Status:  MEDLINE    
The wound-healing process is initiated as soon as the tissue is injured. Herein, we demonstrate that c-fos and c-myc mRNA transcripts are promptly increased in the wounded tissue in vivo and in vitro. A buffer solution from scraped serum-starved quiescent fibroblasts, when added to resting fibroblasts, caused an increase of c-fos and c-myc mRNA among the indicator cells. Soluble factors contained in the wounding supernatant are responsible for these phenomena, and we call them wounding factors. Addition of proteinase inhibitors to the culture medium drastically reduced the c-fos mRNA induction by the wounding factors. Exogenously added trypsin or thrombin mimicked the activity of wounding factors. These results suggest that wounding causes soluble factors including various proteinases to be released from the damaged cells, which trigger the adjacent cells to respond to the injury.
M Hatanaka; K Tsuboi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of tissue reactions     Volume:  13     ISSN:  0250-0868     ISO Abbreviation:  Int J Tissue React     Publication Date:  1991  
Date Detail:
Created Date:  1992-05-14     Completed Date:  1992-05-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302116     Medline TA:  Int J Tissue React     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  249-55     Citation Subset:  IM    
Institute for Virus Research, Kyoto University, Japan.
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MeSH Terms
Blotting, Northern
Cells, Cultured
Endopeptidases / metabolism*,  physiology*
Fibroblasts / chemistry,  metabolism*
Proto-Oncogene Proteins c-fos / analysis,  genetics
Proto-Oncogene Proteins c-myc / analysis,  genetics
RNA, Messenger / analysis,  genetics
Rats, Inbred Strains
Thrombin / pharmacology
Transcription, Genetic / drug effects
Trypsin / pharmacology
Wound Healing / physiology*
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-myc; 0/RNA, Messenger; EC 3.4.-/Endopeptidases; EC; EC

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