Document Detail


Initiation of runaway cell death in an Arabidopsis mutant by extracellular superoxide.
MedLine Citation:
PMID:  8791589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reactive oxygen intermediates (ROIs) regulate apoptosis during normal development and disease in animals. ROIs are also implicated in hypersensitive resistance responses of plants against pathogens. Arabidopsis lsd1 mutants exhibited impaired control of cell death in the absence of pathogen and could not control the spread of cell death once it was initiated. Superoxide was necessary and sufficient to initiate lesion formation; it accumulated before the onset of cell death and subsequently in live cells adjacent to spreading lsd1 lesions. Thus, runaway cell death seen in lsd1 plants reflected abnormal accumulation of superoxide and lack of responsiveness to signals derived from it.
Authors:
T Jabs; R A Dietrich; J L Dangl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  273     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-10-09     Completed Date:  1996-10-09     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1853-6     Citation Subset:  IM    
Affiliation:
Max-Delbrück Laboratory, Carl von Linné Weg 10, 50829 Köln, Germany.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/U87833;  U87834
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MeSH Terms
Descriptor/Qualifier:
Apoptosis*
Arabidopsis / cytology*,  genetics,  metabolism
Cell Membrane / enzymology
Enzyme Inhibitors / pharmacology
Gene Expression Regulation, Plant
Genes, Plant
Glutathione Transferase / genetics,  metabolism
Mutation
NADH, NADPH Oxidoreductases / antagonists & inhibitors,  metabolism
NADPH Oxidase
Onium Compounds / pharmacology
Peroxidases / genetics,  metabolism
Plant Leaves / cytology,  metabolism
RNA, Messenger / genetics,  metabolism
RNA, Plant / genetics,  metabolism
Reactive Oxygen Species / metabolism
Superoxide Dismutase / genetics
Superoxides / metabolism*
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Onium Compounds; 0/RNA, Messenger; 0/RNA, Plant; 0/Reactive Oxygen Species; 11062-77-4/Superoxides; 244-54-2/diphenyleneiodonium; EC 1.11.1.-/Peroxidases; EC 1.15.1.1/Superoxide Dismutase; EC 1.6.-/NADH, NADPH Oxidoreductases; EC 1.6.3.1/NADPH Oxidase; EC 2.5.1.18/Glutathione Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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