Document Detail


Initiation of the primate ovarian cycle with emphasis on perimenarchial and postpartum events.
MedLine Citation:
PMID:  6343287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In collating the issues discussed in this review, we have summarized the initiation of the primate ovarian/menstrual cycle into two conceptual illustrations. Figure 27 depicts the progression of folliculogenesis in perimenarchial monkeys; Figure 28 compares the restoration of recruitment, selection, and maturation of the dominant follicle in postpartum monkeys, with and without an infant at breast. The following conclusions, some tentative or partial, seem warranted by the data. In perimenarchial monkeys: 1. The late pubertal cascade included progression toward greater ovarian asymmetry of estradiol secretion. 2. This asymmetry of estrogen synthesis may be indicative of recruitment and selection of the dominant follicle, even though ovulation is not yet achieved. 3. Quantitative and qualitative changes in pulsatile pituitary gonadotropin secretion accompany the onset of cyclic ovarian function. 4. The enhanced biological activity of LH, especially during the preovulatory surge induced by the instigation of estrogen positive feedback in the advanced postmenarchial interval, may be a critical development step toward normal ovulatory menstrual cycles. In postpartum monkeys: 1. Reestablishment of ovulatory cycles is a gradual process in non-nursing monkeys, with initial follicular growth supporting endometrial proliferation but failing to culminate in ovulation. Immediately thereafter, ovulatory menstrual cycles ensue. 2. After nursing and weaning, resumption of ovulation is prompt, with the first menses coming after the first luteal phase. 3. Gestation-induced refractoriness of the hypothalamic-pituitary unit to estrogen positive feedback or GnRH challenges is highly transient. 4. While nursing continues, inhibition of the H-P-O axis is absolute; but after weaning the reacquisition of its functional integrity is rapid. 5. Nursing sustains the block to estrogen positive feedback, probably emanating from a mechanism(s) distinctly unlike that imposed by the pregnancy milieu. 6. Persistence of postpartum anovulation surely illustrates inadequate tonic gonadotropin secretion, as opposed to constraints arising from an inoperative surge mode of FSH/LH release.
Authors:
R F Williams; G D Hodgen
Related Documents :
11285987 - Determination of the efficiency of controlled ovarian hyperstimulation in the gonadotro...
400717 - Normal pregnancies after treatment of hyperprolactinemia with bromoergocryptine, despit...
18314107 - Defining the proliferative phase endometrial defect.
6790307 - Monitoring of ovulation induction with human menopausal gonadotropin and human chorioni...
23462627 - Maternal plasma biomarkers for down syndrome: present and future.
11379387 - Field evaluation of a bioregulator containing live bacillus cereus spores on health sta...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International review of physiology     Volume:  27     ISSN:  0363-3918     ISO Abbreviation:  Int Rev Physiol     Publication Date:  1983  
Date Detail:
Created Date:  1983-07-29     Completed Date:  1983-07-29     Revised Date:  2010-04-12    
Medline Journal Info:
Nlm Unique ID:  7608349     Medline TA:  Int Rev Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-55     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Corpus Luteum / physiology
Estrogens / secretion
Female
Gonadotropins, Pituitary / secretion
Macaca fascicularis
Macaca mulatta
Menarche*
Menstruation*
Ovarian Follicle / physiology
Ovary / physiology*
Postpartum Period*
Pregnancy
Progesterone / physiology
Chemical
Reg. No./Substance:
0/Estrogens; 0/Gonadotropins, Pituitary; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Enteroplasty: a new concept in the management of benign strictures of the intestine.
Next Document:  Effects of treatment with muramyl dipeptide on resistance to Mycobacterium leprae and Mycobacterium ...