Document Detail

Initiation of C3H/10T1/2 cell transformation by formaldehyde.
MedLine Citation:
PMID:  7306959     Owner:  NLM     Status:  MEDLINE    
The effects of formaldehyde were evaluated in the C3H/10T1/2 Cl 8 cell transformation system. Treatment of the cells with 0.1-2.5 micrograms/ml for formaldehyde alone did not result in significant rates of transformation. If formaldehyde treatment was followed by continuous treatment with 0.1 microgram/ml of the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA), transformed foci were produced. Methanol and formic acid lacked significant transforming activity under either treatment regimen. The results suggest that formaldehyde is an initiating agent for C3H/10T1/2 Cl 8 transformation. The fact that some compounds may act solely as initiators should be considered when this transformation system is used to study chemicals which may interact with cells by mechanisms similar to that of formaldehyde.
D L Ragan; C J Boreiko
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  13     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1982-02-12     Completed Date:  1982-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  325-31     Citation Subset:  IM    
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MeSH Terms
Cell Line
Cell Transformation, Neoplastic / drug effects*
Dose-Response Relationship, Drug
Drug Interactions
Formaldehyde / pharmacology*
Formic Acids / pharmacology
Methanol / pharmacology
Phorbols / pharmacology*
Tetradecanoylphorbol Acetate / pharmacology*
Reg. No./Substance:
0/Carcinogens; 0/Formic Acids; 0/Phorbols; 16561-29-8/Tetradecanoylphorbol Acetate; 50-00-0/Formaldehyde; 67-56-1/Methanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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