| Initiation of C3H/10T1/2 cell transformation by formaldehyde. | |
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MedLine Citation:
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PMID: 7306959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of formaldehyde were evaluated in the C3H/10T1/2 Cl 8 cell transformation system. Treatment of the cells with 0.1-2.5 micrograms/ml for formaldehyde alone did not result in significant rates of transformation. If formaldehyde treatment was followed by continuous treatment with 0.1 microgram/ml of the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA), transformed foci were produced. Methanol and formic acid lacked significant transforming activity under either treatment regimen. The results suggest that formaldehyde is an initiating agent for C3H/10T1/2 Cl 8 transformation. The fact that some compounds may act solely as initiators should be considered when this transformation system is used to study chemicals which may interact with cells by mechanisms similar to that of formaldehyde. |
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Authors:
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D L Ragan; C J Boreiko |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Cancer letters Volume: 13 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1981 Sep |
Date Detail:
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Created Date: 1982-02-12 Completed Date: 1982-02-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 325-31 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinogens Cell Line Cell Transformation, Neoplastic / drug effects* Dose-Response Relationship, Drug Drug Interactions Formaldehyde / pharmacology* Formic Acids / pharmacology Methanol / pharmacology Mice Phorbols / pharmacology* Tetradecanoylphorbol Acetate / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Formic Acids; 0/Phorbols; 16561-29-8/Tetradecanoylphorbol Acetate; 50-00-0/Formaldehyde; 67-56-1/Methanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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