Document Detail


Initiation of C3H/10T1/2 cell transformation by formaldehyde.
MedLine Citation:
PMID:  7306959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of formaldehyde were evaluated in the C3H/10T1/2 Cl 8 cell transformation system. Treatment of the cells with 0.1-2.5 micrograms/ml for formaldehyde alone did not result in significant rates of transformation. If formaldehyde treatment was followed by continuous treatment with 0.1 microgram/ml of the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA), transformed foci were produced. Methanol and formic acid lacked significant transforming activity under either treatment regimen. The results suggest that formaldehyde is an initiating agent for C3H/10T1/2 Cl 8 transformation. The fact that some compounds may act solely as initiators should be considered when this transformation system is used to study chemicals which may interact with cells by mechanisms similar to that of formaldehyde.
Authors:
D L Ragan; C J Boreiko
Related Documents :
1905019 - Suppression of c-jun/ap-1 activation by an inhibitor of tumor promotion in mouse fibrob...
25478999 - Tryptase, a novel angiogenic factor stored in mast cell granules.
7370979 - Tumor-initiating activity of dihydrodiols formed metabolically from 5-methylchrysene.
3803329 - Jute batching oil: a tumor promoter on mouse skin.
18922899 - Arsenic exposure in utero exacerbates skin cancer response in adulthood with contempora...
10357779 - Chemopreventive effect of 4'-demethyl epipodophyllotoxin on dmba/tpa-induced mouse skin...
20117289 - Radiation-associated breast tumors display a distinct gene expression profile.
14639619 - Anti-neovascular therapy by liposomal drug targeted to membrane type-1 matrix metallopr...
20957629 - Bacillus calmette-guerin immunotherapy of bladder cancer induces selection of human leu...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  13     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1982-02-12     Completed Date:  1982-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  325-31     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Carcinogens
Cell Line
Cell Transformation, Neoplastic / drug effects*
Dose-Response Relationship, Drug
Drug Interactions
Formaldehyde / pharmacology*
Formic Acids / pharmacology
Methanol / pharmacology
Mice
Phorbols / pharmacology*
Tetradecanoylphorbol Acetate / pharmacology*
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Formic Acids; 0/Phorbols; 16561-29-8/Tetradecanoylphorbol Acetate; 50-00-0/Formaldehyde; 67-56-1/Methanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The importance of short term exposure of C3H 10T1/2 cells to polycyclic hydrocarbons: evidence for h...
Next Document:  Differential effects of selenium on the growth of mouse mammary cells in vitro.