Document Detail

Initiation of angiogenesis in atherosclerosis: smooth muscle cells as mediators of the angiogenic response to atheroma formation.
MedLine Citation:
PMID:  22867696     Owner:  NLM     Status:  In-Data-Review    
Neovascularization of atherosclerotic lesions favors their progression toward rupture. Despite this pathophysiological importance, data regarding the mechanism(s) initiating plaque neovascularization are scarce. Recent findings indicate that smooth muscle cells located underneath early aortic atheromatous lesions display a pro-angiogenic phenotype, and that lipid mediators derived from these lesions are potent inducers of this phenotypic change. Here, we discuss these new data suggesting that smooth muscle cells could be the central organizers of an angiogenic response initiated by the very first cause of the atheromatous disease, the accumulation and retention of lipids in the arterial wall.
Benoît Ho-Tin-Noé; Jean-Baptiste Michel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  21     ISSN:  1873-2615     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2012-08-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  183-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Univ Paris Diderot, Sorbonne Paris Cité, INSERM UMR698, 75018 Paris, France; and AP-HP, Hop Bichat Claude Bernard, 75018 Paris, France.
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