Document Detail


Initiation of joint attention is associated with morphometric variation in the anterior cingulate cortex of chimpanzees (Pan troglodytes).
MedLine Citation:
PMID:  23300067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In developing human children, joint attention (JA) is an important preverbal skill fundamental to the development of language. Poor JA skills have been described as a behavioral risk factor for some neurodevelopmental disorders, such as autism spectrum disorder. It has been hypothesized that the anterior cingulate cortex (ACC) plays an important role in the development of JA in human children. Here, we tested whether the morphometry and lateralization of the ACC differed between chimpanzees that were classified as either consistently or inconsistently engaging in JA with a human experimenter. Results showed that chimpanzees that performed poorly on the JA task had larger gray matter (GM) volumes in the ACC compared to apes that performed well on the task. In addition, both population-level asymmetries and sex differences in the volume of GM were found within the ACC. Specifically, females had relatively larger GM volumes in two of the three subregions of the ACC compared to males, and significant leftward asymmetries were found for two of the subregions whereas a rightward bias was observed in the third. Based on these findings, we suggest that the ACC plays an important role in mediating JA, not just in humans, but also chimpanzees. We further suggest that the differences found between groups may reflect inherent differences in the amount of white matter within the ACC, thereby suggesting reduced connectivity between the ACC and other cortical regions in chimpanzees with poor JA skills.
Authors:
William D Hopkins; Jared P Taglialatela
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-08
Journal Detail:
Title:  American journal of primatology     Volume:  75     ISSN:  1098-2345     ISO Abbreviation:  Am. J. Primatol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-03-26     Completed Date:  2013-09-18     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  8108949     Medline TA:  Am J Primatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  441-9     Citation Subset:  IM    
Copyright Information:
© 2013 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Attention / physiology*
Behavior, Animal / physiology
Female
Gyrus Cinguli / physiology*
Male
Pan troglodytes / physiology*
Grant Support
ID/Acronym/Agency:
HD-56232/HD/NICHD NIH HHS; HD-60563/HD/NICHD NIH HHS; MH-92923/MH/NIMH NIH HHS; NS-42867/NS/NINDS NIH HHS; P01 HD060563/HD/NICHD NIH HHS; R01 MH092923/MH/NIMH NIH HHS; R01 NS042867/NS/NINDS NIH HHS
Comments/Corrections

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