Document Detail

Initiating regular exercise protects against muscle atrophy from glucocorticoids.
MedLine Citation:
PMID:  3693188     Owner:  NLM     Status:  MEDLINE    
This study was undertaken to examine whether exercise can prevent glucocorticoid-induced muscle atrophy in previously untrained individuals and to evaluate whether the time of hormone administration is a determinant in the muscle's response to glucocorticoids. Female rats were divided into five groups: 1) a sedentary group that received cortisol acetate (CA, 100 mg/kg body wt); 2) a sedentary group that received the dosing vehicle (1% aqueous carboxymethyl cellulose); 3) an exercise group that received CA immediately after each exercise session; 4) an exercise group that received CA 90 min after each exercise session; and 5) an exercise group that received the vehicle. Steroid treatment and exercise (28.7 m/min for 90 min/day) were performed for 11 consecutive days. Initiation of training prevented muscle mass loss by 60% in plantaris (P) muscles and by 25% in gastrocnemius (G) muscles. Time of steroid injection was not related to the muscle sparing response. In the glucocorticoid-treated exercised rats, the activities of citrate synthase, a training marker, increased 60% in P and 37% in G. Thus the exercise appeared to cause a greater recruitment of P muscles. These data support the hypothesis that entering into an exercise program can be effective in retarding glucocorticoid-induced muscle atrophy. The degree of atrophy prevention, however, may be related to the extent that specific muscles are recruited during exercise.
S M Czerwinski; T G Kurowski; T M O'Neill; R C Hickson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  63     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-02-12     Completed Date:  1988-02-12     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1504-10     Citation Subset:  IM; S    
Department of Physical Education, University of Illinois, Chicago 60680.
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MeSH Terms
Body Weight
Citrate (si)-Synthase / metabolism
Hydrocortisone / toxicity*
Muscular Atrophy / chemically induced,  metabolism,  prevention & control*
Physical Education and Training*
Rats, Inbred Strains
Triamcinolone Acetonide / metabolism
Grant Support
Reg. No./Substance:
50-23-7/Hydrocortisone; 76-25-5/Triamcinolone Acetonide; EC (si)-Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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