| Initiating regular exercise protects against muscle atrophy from glucocorticoids. | |
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MedLine Citation:
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PMID: 3693188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was undertaken to examine whether exercise can prevent glucocorticoid-induced muscle atrophy in previously untrained individuals and to evaluate whether the time of hormone administration is a determinant in the muscle's response to glucocorticoids. Female rats were divided into five groups: 1) a sedentary group that received cortisol acetate (CA, 100 mg/kg body wt); 2) a sedentary group that received the dosing vehicle (1% aqueous carboxymethyl cellulose); 3) an exercise group that received CA immediately after each exercise session; 4) an exercise group that received CA 90 min after each exercise session; and 5) an exercise group that received the vehicle. Steroid treatment and exercise (28.7 m/min for 90 min/day) were performed for 11 consecutive days. Initiation of training prevented muscle mass loss by 60% in plantaris (P) muscles and by 25% in gastrocnemius (G) muscles. Time of steroid injection was not related to the muscle sparing response. In the glucocorticoid-treated exercised rats, the activities of citrate synthase, a training marker, increased 60% in P and 37% in G. Thus the exercise appeared to cause a greater recruitment of P muscles. These data support the hypothesis that entering into an exercise program can be effective in retarding glucocorticoid-induced muscle atrophy. The degree of atrophy prevention, however, may be related to the extent that specific muscles are recruited during exercise. |
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Authors:
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S M Czerwinski; T G Kurowski; T M O'Neill; R C Hickson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 63 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1987 Oct |
Date Detail:
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Created Date: 1988-02-12 Completed Date: 1988-02-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1504-10 Citation Subset: IM; S |
Affiliation:
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Department of Physical Education, University of Illinois, Chicago 60680. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight Citrate (si)-Synthase / metabolism Female Hydrocortisone / toxicity* Muscular Atrophy / chemically induced, metabolism, prevention & control* Physical Education and Training* Rats Rats, Inbred Strains Triamcinolone Acetonide / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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K04 AM-01100/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone; 76-25-5/Triamcinolone Acetonide; EC 2.3.3.1/Citrate (si)-Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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