Document Detail

Initially elevated osteoprotegerin serum levels may predict a perioperative myocardial lesion in patients undergoing coronary artery bypass grafting.
MedLine Citation:
PMID:  16374159     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We investigated whether osteoprotegerin (OPG), an important regulator in the genesis of arteriosclerosis and bone formation, is able to identify patients at risk for perioperative myocardial infarction measured as cardiac troponin I (cTNI) and signs of myocardial ischemia in the electrocardiogram after coronary artery bypass grafting (CABG). DESIGN: Observational study. SETTING: Post-surgical intensive care unit of a tertiary care center. PATIENTS: Ninety-seven patients undergoing elective CABG. INTERVENTIONS: None. MEASUREMENT AND MAIN RESULTS: OPG and cTNI were measured before and 24 hrs after CABG. Additionally, cTNI was measured after 12 hrs. Electrocardiography was done before and immediately after CABG. OPG before CABG (OPGpre) measurements correlated with cTNI measurements after 12 hrs (cTNI12) (r = 0.56; p < .0001) and with cTNI measurements after 24 hrs (cTNI24) (r = 0.77; p < .0001). OPGpre measurements correlated with electrocardiographic findings after surgery (r = 0.65; p < .0001). There was a positive correlation between OPGpre value and the number of bypasses (r = 0.95; p < .0001). A strong correlation was found between OPGpre and homocysteine (r = 0.96; p < .0001). The median OPG presurgical level for the four patients with cardiac complications was found to be notably elevated (28.1 [26.6/31.0] pmol/L) in comparison with that for patients without complications (10.2 [3.7/16.9] pmol/L). CONCLUSIONS: OPG appears to be a useful marker for estimating risk for perioperative myocardial infarction in patients undergoing CABG, as demonstrated by signs of ischemia on electrocardiography.
K M Hermann-Arnhof; T Kästenbauer; T Publig; P Novotny; N Loho; S Schwarz; U Köller; R Fitzgerald
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  34     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-23     Completed Date:  2006-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  76-80     Citation Subset:  AIM; IM    
Department for Clinical and Chemical Laboratory-Diagnostic, Hospital Lainz, Austria.
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MeSH Terms
Biological Markers / blood
Cohort Studies
Confidence Intervals
Coronary Artery Bypass / adverse effects,  methods*
Coronary Disease / radiography,  surgery*
Glycoproteins / blood*,  metabolism
Graft Rejection
Graft Survival
Middle Aged
Perioperative Care / methods
Postoperative Complications / blood,  diagnosis
Predictive Value of Tests
Receptors, Cytoplasmic and Nuclear / blood*,  metabolism
Receptors, Tumor Necrosis Factor / blood*,  metabolism
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Biological Markers; 0/Glycoproteins; 0/Osteoprotegerin; 0/Receptors, Cytoplasmic and Nuclear; 0/Receptors, Tumor Necrosis Factor; 0/TNFRSF11B protein, human

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