Document Detail

Initial and subsequent cytogenetic studies in malignant lymphoma.
MedLine Citation:
PMID:  3315179     Owner:  NLM     Status:  MEDLINE    
Two or more cytogenetic studies of lymph node biopsy specimens from 12 patients with non-Hodgkin's malignant lymphoma were performed. Each of the 12 patients had at least one clonal structural chromosome abnormality in their initial biopsy specimen. A comparison of the chromosome abnormalities in the initial lymph node biopsy specimens with those in subsequent biopsy specimens was made. Structural and numerical chromosome changes were not always accompanied by a change in the histologic type of the lymphoma. Similarly, a change in histologic type was not always associated with the appearance of new structural or numerical abnormalities. Serial cytogenetic studies from additional patients will further our understanding relevant to which chromosome changes are associated with lymphomagenesis and which are secondary or more of an evolutionary nature.
W G Sanger; J O Armitage; J Bridge; D D Weisenburger; R Fordyce; D T Purtilo
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer     Volume:  60     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-01-04     Completed Date:  1988-01-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3014-9     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Nebraska Medical Center, Omaha.
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MeSH Terms
Aged, 80 and over
Chromosome Aberrations*
Follow-Up Studies
Leukemia, Lymphocytic, Chronic, B-Cell / genetics,  pathology
Lymph Nodes / pathology
Lymphoma, Follicular / genetics,  pathology
Lymphoma, Non-Hodgkin / genetics*,  pathology
Middle Aged
Grant Support

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