Document Detail


Initial studies on the penetration of spirohydantoin mustard into the cerebrospinal fluid of dogs.
MedLine Citation:
PMID:  896953     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A gas-chromatographic-mass-spectrometric method using selected ion monitoring has been developed to detect and quantitate levels of spirohydantoin mustard (SHM) as low as 1 ng per injected sample. The ions chosen for analysis of the drug were at m/e 154, 156, and 299. Using this procedure, the distribution of SHM in the blood and cerebrospinal fluid (CSF) of dogs following intravenous administration has been studied. The initial blood decay of SHM is rapid with a half-life of 1.78 and 1.85 min for 2 different dogs. SHM enters the CSF and, after reaching a peak value at approximately 10 min, exhibits a decay curve similar to that found in blood.
Authors:
J Plowman; D B Lakings; E S Owens; R H Adamson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology     Volume:  15     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  1977  
Date Detail:
Created Date:  1977-10-28     Completed Date:  1977-10-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  359-66     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents
Chemical Phenomena
Chemistry
Dogs
Female
Half-Life
Hydantoins / administration & dosage,  blood,  cerebrospinal fluid*
Injections, Intravenous
Nitrogen Mustard Compounds / administration & dosage,  blood,  cerebrospinal fluid*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Hydantoins; 0/Nitrogen Mustard Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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