Document Detail


Initial photochemistry of bilirubin probed by femtosecond spectroscopy.
MedLine Citation:
PMID:  17927274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bilirubin is a breakdown product from heme catabolism, and reduced excretion of bilirubin can lead to jaundice. Phototherapy is the most common treatment for neonatal jaundice, a condition frequently encountered in newborn infants. Knowledge of the photochemistry of bilirubin, which is dominated by (ultra)fast components, is necessary for the profound understanding of the processes in phototherapy. Here, we report results from femtosecond fluorescence upconversion measurements on bilirubin and half-bilirubin model compounds, as well as pump-probe absorption measurements on bilirubin. A fast component of ca. 120 fs in the multiexponential fluorescence decay, being only visible in the bilirubin molecule, is interpreted as exciton localization within the molecular halves. The slower components of several hundreds of femtoseconds and a few picoseconds, occurring in bilirubin and the half-bilirubin model, are interpreted as relaxation to a (twisted) intermediate, which decays further with ca. 15 ps to the ground state.
Authors:
Burkhard Zietz; Tomas Gillbro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of physical chemistry. B     Volume:  111     ISSN:  1520-6106     ISO Abbreviation:  J Phys Chem B     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-11     Completed Date:  2007-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101157530     Medline TA:  J Phys Chem B     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11997-2003     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Biophysical Chemistry, Umeå University, SE-90187, Umeå, Sweden. burkhard.zietz@ipcms.u-strasbg.fr
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MeSH Terms
Descriptor/Qualifier:
Bilirubin / chemistry*
Kinetics
Molecular Structure
Photochemistry
Spectrometry, Fluorescence / methods*
Chemical
Reg. No./Substance:
635-65-4/Bilirubin

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