Document Detail

Initial lymphocyte count and the development of persistent/chronic immune thrombocytopenic purpura.
MedLine Citation:
PMID:  20658623     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acute immune thrombocytopenic purpura (ITP) is a common, benign, self-limiting disease in children. Chronic ITP is diagnosed when thorombocytopenia persists beyond 12 months. Older age is associated with increased risk for development of chronic ITP. The main objective of the current study was to examine whether total leukocyte (TLC) and absolute lymphocyte counts (ALC) at diagnosis correlate with the persistence of ITP beyond 6 months. PROCEDURE: Two hundred and twenty four consecutive medical records for patients diagnosed with immune thrombocytopenia, between April 1993 and July 2007, were reviewed and 188 patients were eligible for analysis. Case records were examined to ascertain the following information: age, gender, ethnicity, date of presentation, presenting CBC with differential count, treatment given and the outcome. RESULTS: The male to female ratio was almost 1:1; 24% (45/188) of patients had persistent ITP beyond 6 months. We determined that age >8.5 year, TLC < 6,250/microl and ALC < 3,050/microl was associated with a significant risk for development of persistent ITP beyond 6 months. CONCLUSIONS: TLC and ALC at diagnosis are predictive variables for the development of persistent/chronic ITP. Further studies are recommended to confirm the current finding and to assess the underlying pathophysiology with the course of the ITP.
Ibrahim Ahmed; Madhvi Rajpurkar; Ronald Thomas; Meera Chitlur
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  55     ISSN:  1545-5017     ISO Abbreviation:  Pediatr Blood Cancer     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  508-11     Citation Subset:  IM    
Copyright Information:
2010 Wiley-Liss, Inc.
The Carman and Ann Adams Department of Pediatrics, Pediatric Hematology/Oncology Division, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan, USA.
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MeSH Terms
Biological Markers / blood
Child, Preschool
Chronic Disease
Lymphocyte Count*
Platelet Count
Predictive Value of Tests
Purpura, Thrombocytopenic, Idiopathic / blood,  diagnosis*
ROC Curve
Sensitivity and Specificity
Reg. No./Substance:
0/Biological Markers

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