Document Detail

Initial (latent) polycythemia vera with thrombocytosis mimicking essential thrombocythemia.
MedLine Citation:
PMID:  15983426     Owner:  NLM     Status:  MEDLINE    
Patients have previously been described who showed clinical signs and symptoms suggesting essential thrombocythemia (ET), but later transformed to polycythemia vera (PV). From a series of 344 patients with a sustained borderline to moderate erythrocytosis, 44 failed to conform initially with the diagnostic criteria of the WHO for PV, because of their low hemoglobin level. Twenty-three patients of this group presented with a thrombocytosis exceeding 600 x 10(9)/l and therefore suggested ET, but later developed full-blown PV. For comparison we investigated also 164 patients with manifest PV, 90 patients with ET and 22 patients with reactive thrombocytosis (Th). The histopathology of initial PV was evaluated by stepwise discriminant analysis of 17 standardized features. Quantity and left shifting of erythro- and granulopoiesis, giant forms and naked nuclei of megakaryocytes, cellularity and reticulin fibers proved to exert a significant relevance concerning differentiation from true ET and Th. In conclusion, initial PV with thrombocytosis is characterized by a special pattern of BM histopathology. Therefore, so-called masked PV in patients with ET or simultaneous PVR-1 gene expression and endogeneous erythroid colony growth in ET patients are probably in keeping with initial PV mimicking ET.
Jurgen Thiele; Hans Michael Kvasnicka; Volker Diehl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta haematologica     Volume:  113     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  2005  
Date Detail:
Created Date:  2005-06-28     Completed Date:  2005-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  213-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 S. Karger AG, Basel
Institute of Pathology, University of Cologne, Cologne, Germany.
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MeSH Terms
Discriminant Analysis
Middle Aged
Polycythemia Vera / complications*,  diagnosis*
Retrospective Studies
Thrombocytosis / complications*,  diagnosis*

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