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Initial findings of impact of strut width on stent coverage and apposition of sirolimus-eluting stents assessed by optical coherence tomography.
MedLine Citation:
PMID:  22517601     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: We investigate the influence of stent design on stent coverage at 6 to 9 months after sirolimus eluting stent (SES) implantation using optical coherence tomography (OCT). BACKGROUND: Although some reports suggest that stent design may correlate with stent coverage of stent struts, there was few detailed data whether stent design impact on stent coverage in the same drug-eluting stent. METHODS: A total of 21 SESs (15 patients), who had implanted 2.5, 2.75 and 3.0mm-stents, underwent OCT at 6 to 9 months after stent implantaiton. SES is constructed by two different strut width-components; narrow strut width parts (59μm) and wide strut width parts (115μm). Thus, we divided stent struts of SESs into two groups: narrow strut width parts (narrow group) and wide ones (wide group). We compared the incidence of incomplete apposed struts, uncovered struts and neointimal hyperplasia (NIH) thickness between the two groups. RESULTS: We could detect 2948 struts (narrow group consisted of 1132 struts and wide group consisted of 1816 struts). Incidence of uncovered struts in the narrow group was significantly lower than in the wide group (30.2% vs. 40.8%, P<0.001) and NIH thickness in the narrow group was significantly greater than in the wide group (127.5 ± 93.4μm vs. 118.6 ± 81.4μm, P=0.03). CONCLUSIONS: Stent design, especially strut width, affects stent coverage of SES. The narrow strut may avoid the absence of stent coverage in SES, which correlates with stent thrombosis. © 2012 Wiley Periodicals, Inc.
Authors:
Shimpei Nakatani; Masami Nishino; Masayuki Taniike; Nobuhiko Makino; Hiroyasu Kato; Yasuyuki Egami; Ryu Shutta; Jun Tanouchi; Yoshio Yamada
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-19
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  -     ISSN:  1522-726X     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Division of Cardiology, Osaka Rosai Hospital, Osaka, Japan.
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