Document Detail

Initial experience with laparoscopic ultrasound-guided radiofrequency thermal ablation of hepatic tumours.
MedLine Citation:
PMID:  10376460     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND STUDY AIMS: Radiofrequency (RF) thermal ablation has been applied almost exclusively through the percutaneous approach under radiological/external ultrasound guidance. We have embarked on a programme of laparoscopic ultrasound-guided RF ablation of hepatic tumours in view of the potential advantages of this approach, i. e. reduced heat sink effect, greater precision and improved assessment of the thermal ablative zone. PATIENTS AND METHODS: RF thermal ablation using the Zomed International generator and multielectrode probes in two patients with hepatoma arising on a background of cirrhosis and in eight patients with multiple deposits from primary colorectal cancer. RESULTS: Total ablation was performed in two patients with hepatoma and 7/8 patients with secondary deposits. Total ablation with a minimum of 0.5-cm margin was achieved in 32 lesions. No complications were encountered postoperatively and all patients were discharged within 2 days of the intervention. One patient in whom thermal ablation was not completed has since died of progressive disease, eight appear to be free of tumour (follow-up 6-20 months) but one patient has developed further secondary hepatic deposits. CONCLUSIONS: The initial experience with laparoscopic ultrasound-guided RF ablation of hepatic tumours indicates its safety and therapeutic potential in patients with inoperable hepatic tumours.
A Cuschieri; J Bracken; L Boni
Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase II; Journal Article    
Journal Detail:
Title:  Endoscopy     Volume:  31     ISSN:  0013-726X     ISO Abbreviation:  Endoscopy     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-08-23     Completed Date:  1999-08-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0215166     Medline TA:  Endoscopy     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  318-21     Citation Subset:  IM    
Dept. of Surgery, Ninewells Hospital and Medical School, University of Dundee, Scotland.
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MeSH Terms
Carcinoma, Hepatocellular / secondary,  surgery*,  ultrasonography
Catheter Ablation / methods*
Colorectal Neoplasms / pathology
Laparoscopy / methods*
Liver Neoplasms / secondary,  surgery*,  ultrasonography
Middle Aged
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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