Document Detail


Initial experience with fenoldopam in children.
MedLine Citation:
PMID:  11329109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fenoldopam is a direct-acting vasodilator that acts at the postsynaptic dopamine 1 receptors in renal, coronary, cerebral, and splanchnic vasculature resulting in arterial dilation and a lowering of the mean arterial pressure (MAP). Preliminary evidence suggests its efficacy in the treatment of hypertensive urgencies and emergencies in adults. We present four children in whom fenoldopam was used to control MAP in various clinical scenarios, including hypertensive emergencies and urgencies, intraoperative reduction of MAP for controlled hypotension, and control of MAP during extracorporeal membrane oxygenation. The possible applications of fenoldopam and suggested dosing regimens in children are reviewed.
Authors:
L M Strauser; R D Pruitt; J D Tobias
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  American journal of therapeutics     Volume:  6     ISSN:  1075-2765     ISO Abbreviation:  Am J Ther     Publication Date:  1999 Sep 
Date Detail:
Created Date:  2001-04-30     Completed Date:  2001-06-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9441347     Medline TA:  Am J Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  283-8     Citation Subset:  IM    
Affiliation:
Department of Child Health, Division of Pediatric Critical Care/Pediatric Anesthesiology, University of Missouri, Columbia, MI 65212, USA.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Antihypertensive Agents / pharmacology,  therapeutic use*
Body Weight
Brain Neoplasms / surgery
Child
Dopamine Agonists / pharmacology,  therapeutic use*
Emergencies
Female
Fenoldopam / pharmacology,  therapeutic use*
Humans
Hypertension / drug therapy*,  etiology
Infant
Infusions, Intravenous
Intraoperative Complications / drug therapy,  etiology
Male
Medulloblastoma / surgery
Near Drowning / complications
Postoperative Complications / drug therapy,  etiology
Scoliosis / surgery
Vasodilator Agents / pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Dopamine Agonists; 0/Vasodilator Agents; 67227-56-9/Fenoldopam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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