| Initial experience with bosentan therapy in patients with the Eisenmenger syndrome. | |
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MedLine Citation:
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PMID: 15246919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bosentan, an endothelin-1 antagonist that can be administered orally, has been shown to be effective in the treatment of idiopathic pulmonary arterial hypertension and may be of benefit to patients with the Eisenmenger syndrome. Nine patients with Eisenmenger's syndrome were treated with bosentan at a dose of 125 mg twice a day. After treatment with bosentan, 6 of 9 patients (67%) had an improvement in New York Heart Assocation classification of >/=1 grades (p = 0.03). Oxygen saturation levels increased from 79 +/- 5% to 88 +/- 6%, (p = 0.03). The side effects of bosentan therapy were minor; no significant changes in liver function tests were noted. These preliminary data suggest that oral administration of bosentan therapy for Eisenmenger's syndrome results in improved oxygenation and functional status with minimal side effects. |
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Authors:
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Douglas D Christensen; Michael E McConnell; Wendy M Book; William T Mahle |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of cardiology Volume: 94 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-07-12 Completed Date: 2004-08-10 Revised Date: 2005-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 261-3 Citation Subset: AIM; IM |
Affiliation:
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Children's Healthcare of Atlanta, Atlanta, Georgia, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antihypertensive Agents / therapeutic use* Eisenmenger Complex / drug therapy* Endothelin-1 / antagonists & inhibitors Female Humans Male Middle Aged Retrospective Studies Sulfonamides / pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Endothelin-1; 0/Sulfonamides; 147536-97-8/bosentan |
| Comments/Corrections | |
Comment In:
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Am J Cardiol. 2005 Feb 1;95(3):435-6; author reply 436
[PMID:
15670566
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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