| Initial experience with 18F-fluoroethylcholine PET/CT in staging and monitoring therapy response of advanced renal cell carcinoma. | |
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MedLine Citation:
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PMID: 20390384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The use of 18F-fluoroethylcholine (FEC) PET/ CT in staging and monitoring therapy response of advanced renal cell carcinoma (RCC) was prospectively analysed. METHODS: Preliminary results of two patients with metastatic RCC who underwent tumour nephrectomy as well as FEC PET/CT before and 10 weeks after two cycles of tyrosine kinase inhibitor therapy are presented. RESULTS: All in all, 18 tumour lesions were detected by baseline PET/CT, of which 10 (56%) were positive in FEC PET and 17 (94%) visible on contrast-enhanced computed tomography (ceCT). Mainly, small lung metastases resulted in the lower detection rate of FEC PET compared with ceCT. In follow-up PET/CT of the first case, progressive disease (PD) occurred with increase in tumour diameters of all metastases but non-uniform metabolic response. In the second case, partial response (PR) was achieved with concordant results of PET and CT. These results were confirmed by further CT in the course of disease. CONCLUSIONS: In this small sample more than half of the RCC metastases were evident in baseline FEC PET. Monitoring therapy, FEC PET showed heterogeneous results in the first case with PD and was consistent with ceCT in the second one displaying PR. |
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Authors:
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Marcus Middendorp; Luise Maute; Bruno Sauter; Thomas J Vogl; Frank Grünwald |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-04-15 |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 24 ISSN: 1864-6433 ISO Abbreviation: Ann Nucl Med Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-20 Completed Date: 2010-11-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
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Languages: eng Pagination: 441-6 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Hospital of JW Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. marcus.middendorp@kgu.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma, Renal Cell / diagnosis*, pathology*, therapy Choline / analogs & derivatives*, diagnostic use Humans Kidney Neoplasms / diagnosis*, pathology*, therapy Male Neoplasm Staging Positron-Emission Tomography* Tomography, X-Ray Computed* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/fluoroethylcholine; 62-49-7/Choline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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