| Initial evaluation of the nonsmall cell lung cancer patient: diagnosis and staging. | |
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MedLine Citation:
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PMID: 20453649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: The initial diagnosis and staging of nonsmall cell lung cancer patients is complex and involves multiple technologies. This review evaluates the recent literature and integrates it into a systematic method for evaluating patients. RECENT FINDINGS: The goal of the initial diagnosis and staging of nonsmall cell lung cancer is to provide sufficient information to allow definitive treatment. Initial steps should include a history and physical, basic laboratory tests, pulmonary functions, and PET-computed tomography (CT) imaging. If there is evidence of metastatic disease, then biopsy of the most advanced lesion is warranted. If there is no evidence of metastatic disease, the evaluation should focus on evaluation of the mediastinal lymph nodes. If there is evidence of nodal involvement by PET-CT, then endobronchial ultrasound-guided transbronchial needle aspiration is warranted. If there is no evidence of nodal involvement on PET-CT, then either surgery or CT-guided fine needle aspiration is warranted. Other factors that should be kept in mind when selecting a diagnostic strategy include whether or not the patient is a surgical candidate, the impact of comorbidities, the type of cancer, the need for predictive biomarker analysis, and the range of possible treatment options. SUMMARY: Integrating new technologies such as PET-CT and endobronchial ultrasound into the initial evaluation of patients can save unnecessary diagnostic procedures and lead to more rapid and accurate staging. |
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Authors:
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Francisco A Almeida; Mateen Uzbeck; David Ost |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in pulmonary medicine Volume: 16 ISSN: 1531-6971 ISO Abbreviation: Curr Opin Pulm Med Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-09 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503765 Medline TA: Curr Opin Pulm Med Country: United States |
Other Details:
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Languages: eng Pagination: 307-14 Citation Subset: IM |
Affiliation:
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Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy Carcinoma, Non-Small-Cell Lung / diagnosis*, pathology Diagnosis, Differential Endosonography Humans Lung Neoplasms / diagnosis*, pathology Lymphatic Metastasis / diagnosis, pathology Medical History Taking Neoplasm Staging Physical Examination Positron-Emission Tomography Respiratory Function Tests Tomography, X-Ray Computed Tumor Markers, Biological / analysis |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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