| Initial evaluation of a nano-engineered hemostatic agent in a severe vascular and organ hemorrhage swine model. | |
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MedLine Citation:
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PMID: 22914081 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: An advanced hemostatic dressing, Rapid Trauma Hemostat (RTH), was developed using nano-engineered inorganic nanofibers with hemostatic surface properties. METHODS: Yorkshire swine were treated with RTH or Combat Gauze (CBG) to stop bleeding from either an arterial puncture (G-RTH and G-CBG) or a liver lobe laceration (L-RTH and L-CBG). All animals received 500 mL of Hextend at 10 minutes after injury and were monitored for a total time of 180 minutes. RESULTS: Uncontrolled hemorrhage was similar in all animals in both models and was immediately controlled with the application of either dressing. After blood pressure was restored with fluid resuscitation, the RTH hemostatic treatment was less effective than CBG in the groin (puncture) model (rebleeding incidence, four of seven for G-RTH vs. one of seven for G-CBG; p = 0.034) but showed similar efficacy in the liver injury model (lower pressure bleeding). Interestingly, RTH exhibited a trend for higher efficacy in terms of hemostatic plug formation at the end of the experiment (no bleeding occurred after dressing removal) in the liver injury model. CONCLUSION: Overall, RTH was not as effective at stopping high-shear rate (arterial) bleeding, but it presented some advantages for intracavitary treatment with potential for long-term evacuation. |
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Authors:
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Françoise Arnaud; Tomoaki Okada; Daniel Solomon; Ashraful Haque; Erica E Carroll; Eilleen Sagini; Richard McCarron |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-20 |
Journal Detail:
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Title: The journal of trauma and acute care surgery Volume: - ISSN: 2163-0763 ISO Abbreviation: J Trauma Acute Care Surg Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101570622 Medline TA: J Trauma Acute Care Surg Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Department of NeuroTrauma (F.A., T.O., A.H., E.S., R.M.), Operational and Undersea Medicine, Naval Medical Research Center, Silver Spring, Maryland; Department of Surgery (F.A., R.M.), Uniformed Services University of Health Science, Bethesda, Maryland; Department of Surgery (D.S.), Yale University, New Haven, Connecticut; and Department of Pathology (E.E.C.), Naval Medical Research Center, Silver Spring, Maryland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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