| Initial evaluation of dynamic human imaging using 18F-FRP170 as a new PET tracer for imaging hypoxia. | |
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MedLine Citation:
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PMID: 17424976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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18F-FRP170, 1-(2-fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole, is a new hypoxia imaging agent for positron emission tomography. This compound was synthesized by 18F-labeling of RP170, which was developed as a new hydrophilic 2-nitroimidazole analog. In the present study, we analyzed dynamic whole-body imaging in healthy volunteers and dynamic tumor imaging in three patients with lung cancer. METHODS: Four healthy male volunteers and three lung cancer patients were enrolled in this study. Volunteers underwent dynamic whole-body scans just after injection of 18F-FRP170 for about 90 min, while the lung cancer patients underwent dynamic tumor imaging for about 60 or 120 min. Data are expressed as standardized uptake values (SUV). Regions of interest were placed over images of each organ or tumor to generate time-SUV curves. RESULTS: The series of dynamic whole-body scans showed rapid elimination of 18F-FRP170 from the kidneys following elimination from the liver. Very low physiological uptake was observed above the diaphragm. 18F-FRP170 uptake in the lung cancer lesion could be visualized clearly from early after injection. The changes of tumor SUV, tumor/blood ratio, or tumor/muscle ratio about 30 min after injection or later were small. CONCLUSIONS: Dynamic imaging using 18F-FRP170 demonstrated rapid elimination from the kidney, suggesting the high hydrophilicity of this imaging agent. The background activity above the diaphragm was very low, and patients with lung cancer showed clear tumor uptake of 18F-FRP170 early after injection. |
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Authors:
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Tomohiro Kaneta; Yoshihiro Takai; Ren Iwata; Takashi Hakamatsuka; Hiroyasu Yasuda; Katsutoshi Nakayama; Yoichi Ishikawa; Shoichi Watanuki; Shozo Furumoto; Yoshihito Funaki; Eiko Nakata; Keiichi Jingu; Michihiko Tsujitani; Masatoshi Ito; Hiroshi Fukuda; Shoki Takahashi; Shogo Yamada |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 21 ISSN: 0914-7187 ISO Abbreviation: Ann Nucl Med Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-04-11 Completed Date: 2007-06-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
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Languages: eng Pagination: 101-7 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology, Tohoku University, Sendai, Japan. kaneta@rad.med.tohoku.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Female Humans Lung Neoplasms / metabolism*, radionuclide imaging* Male Middle Aged Nitroimidazoles / diagnostic use*, pharmacokinetics* Organ Specificity Pilot Projects Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use, pharmacokinetics Reproducibility of Results Sensitivity and Specificity Tissue Distribution Whole Body Imaging / methods* |
| Chemical | |
Reg. No./Substance:
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0/FRP-170; 0/Nitroimidazoles; 0/Radiopharmaceuticals |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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