| Initial evaluation of CYFRA 21-1 diagnostic performances as a urinary marker in bladder transitional cell carcinoma. | |
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MedLine Citation:
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PMID: 9224298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: CYFRA 21-1, an immunoradiometric assay developed for the detection of a soluble cytokeratin 19 fragment, is evaluated for its diagnostic performance in urine of patients with transitional cell carcinoma. MATERIALS AND METHODS: CYFRA 21-1 was investigated in serum and urine of 128 patients, including 48 with bladder transitional cell carcinoma (group 1), 44 with other urological pathological conditions (group 2) and 36 free of urothelial disease (group 3). Urinary cytopathology was also performed. RESULTS: Mean urinary CYFRA was 123.5 +/- 53, 11.9 +/- 4.8 and 2.3 +/- 0.2 ng./ml. for groups 1 to 3, respectively, and was significantly different. From the receiver operating characteristics curve, the optimal combination of 96% sensitivity and 74% specificity was determined for a threshold value of 4 ng./ml. while overall cytopathology sensitivity was 43%. CONCLUSIONS: Urinary CYFRA 21-1 may be a useful marker for diagnosing transitional cell carcinoma. |
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Authors:
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J L Pariente; L Bordenave; P Michel; M J Latapie; D Ducassou; M Le Guillou |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of urology Volume: 158 ISSN: 0022-5347 ISO Abbreviation: J. Urol. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-08-15 Completed Date: 1997-08-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 338-41 Citation Subset: AIM; IM |
Affiliation:
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Department of Urology, Pellegrin Hospital, Bordeaux, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma, Transitional Cell / blood, urine* Female Humans Immunoradiometric Assay* Keratins / blood, urine* Male Middle Aged ROC Curve Sensitivity and Specificity Tumor Markers, Biological / blood, urine* Urinary Bladder Neoplasms / blood, urine* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological; 68238-35-7/Keratins |
| Comments/Corrections | |
Comment In:
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J Urol. 1998 Sep;160(3 Pt 1):838
[PMID:
9720567
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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