| Initial diagnosis of leprosy in patients treated by an ophthalmologist and confirmation by conventional analysis and polymerase chain reaction. | |
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MedLine Citation:
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PMID: 17532046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To report the initial diagnosis of leprosy in patients seeking treatment from an ophthalmologist in a tertiary eye care center, its confirmation by histopathologic and polymerase chain reaction analysis, and review of literature. DESIGN: Noncomparative retrospective case series. PARTICIPANTS: Patients with no known history of leprosy who were selected based on either a clinical suspicion or a histopathologic diagnosis and were found to have ocular or periocular lesions suggestive of leprosy. METHODS: Review of clinical records of patients with no known history of leprosy seen by an ophthalmologist at a tertiary eye care referral center. MAIN OUTCOME MEASURES: Patient demographics, presenting symptoms and signs, diagnostic studies, complications, and treatment. RESULTS: Among the 6 patients (5 women and 1 man; average age, 55 years), only 2 were found to have leprosy from clinical examination alone. Histopathologic characteristics or demonstration of acid-fast bacilli, suggestive of leprosy, were found in 5 patients. Definite confirmation of leprosy was made by polymerase chain reaction performed on formalin-fixed, paraffin-embedded tissues of 4 patients having suspected leprosy based on clinicohistopathologic examination results. CONCLUSIONS: The diagnosis of leprosy relies on the clinical symptom complex, epidemiologic factors, and demonstration of acid-fast bacilli in the tissue sample. Considering that the global leprosy population is 12 million, a patient with leprosy may be found anywhere. The ophthalmologist may be the first one to encounter such patient, in which case suspicion and detection of ocular findings may lead to early treatment of the infection. Polymerase chain reaction may be a new tool in the definite diagnosis of leprosy when suspicion of the diseases is raised by clinicohistopathologic studies. |
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Authors:
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Imtiaz A Chaudhry; Farrukh A Shamsi; Elsanusi Elzaridi; Abdulaziz Awad; Hamad Al-Fraikh; Mohammed Al-Amry; Hassan Al-Dhibi; Fenwick C Riley |
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Publication Detail:
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Type: Journal Article Date: 2007-05-29 |
Journal Detail:
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Title: Ophthalmology Volume: 114 ISSN: 1549-4713 ISO Abbreviation: Ophthalmology Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-02 Completed Date: 2007-10-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: United States |
Other Details:
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Languages: eng Pagination: 1904-11 Citation Subset: IM |
Affiliation:
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Oculoplastic and Orbit Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. orbitdr@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged DNA Primers / chemistry DNA, Bacterial / analysis Eye Infections, Bacterial / diagnosis*, drug therapy, microbiology Female Humans Leprostatic Agents / therapeutic use Leprosy / diagnosis*, drug therapy, microbiology Male Middle Aged Mycobacterium leprae / genetics, isolation & purification* Ophthalmology Polymerase Chain Reaction Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/DNA, Bacterial; 0/Leprostatic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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