Document Detail

Initial defibrillation versus initial chest compression in a 4-minute ventricular fibrillation canine model of cardiac arrest.
MedLine Citation:
PMID:  19455026     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Previous laboratory and clinical studies have demonstrated that chest compression preceding defibrillation in prolonged ventricular fibrillation (VF) increases the likelihood of successful cardiac resuscitation. The lower limit of VF duration when preshock chest compression provides no benefit has not been specifically studied. We aimed to study the effect of order of defibrillation and chest compression on defibrillation and cardiac resuscitation in a 4-minute VF canine model of cardiac arrest. DESIGN: Prospective, randomized animal study. SETTING: Key Laboratory of Cardiovascular Remodeling and Function Research and Department of Cardiology, QiLu Hospital. SUBJECTS: Twenty-four domestic dogs. INTERVENTIONS: VF was induced in anesthetized and ventilated canines. After 4 minutes of untreated VF, animals were randomly assigned to receive shock first or chest compression first. Animals in the shock-first group received an immediate single countershock of 360 J for <10 seconds, then 200 immediate compressions before pulse check or rhythm reanalysis. The ratio of compression to ventilation was 30:2. Interruptions to deliver rescue breaths were eliminated in this study. Animals in the chest compression-first group received 200 chest compressions before a single countershock; the other interventions were the same as for the shock-first group. End points were restoration of spontaneous circulation (ROSC), defined as spontaneous systolic arterial pressure >50 mm Hg, when epinephrine (0.02 mg/kg intravenously) was given, and resuscitation, defined as maintaining systolic arterial pressure >50 mm Hg at the 24-hour study end point. MEASUREMENTS AND MAIN RESULTS: In the shock-first group, all animals achieved ROSC, and ten of 12 survived at the 24-hour study end point. In the chest compression-first group, 11 of 12 animals achieved ROSC, and nine of 12 survived at the 24-hour study end point. CONCLUSIONS: In this 4-minute VF canine model of cardiac arrest, the order of initial defibrillation or initial chest compression does not affect cardiac resuscitation.
Yuan-Long Wang; Jing-Quan Zhong; Wen Tao; Xue-Mei Hou; Xiang-Lin Meng; Yun Zhang
Related Documents :
6190616 - Resuscitation in hypovolemia and shock: a prospective study of hydroxyethyl starch and ...
11719176 - Haemodynamic and volumetric monitoring during haemorrhagic shock in swine.
8102886 - Resuscitation of pigs with haemorrhagic shock by an intraosseous hyperosmotic solution ...
3896056 - Science and shock: a clinical perspective.
16308106 - Roles of mmp-2/-9 in cardiac dysfunction during early multiple organ failure in an ovin...
2693656 - Antihypertensive therapy and the progression of renal disease.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  37     ISSN:  1530-0293     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-18     Completed Date:  2009-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2250-2     Citation Subset:  AIM; IM    
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Jinan, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure
Cardiopulmonary Resuscitation / methods*
Disease Models, Animal
Electric Countershock*
Heart Arrest / etiology,  physiopathology,  therapy*
Heart Massage*
Heart Rate
Time Factors
Ventricular Fibrillation / complications,  physiopathology,  therapy*
Comment In:
Crit Care Med. 2009 Jul;37(7):2316-7   [PMID:  19535931 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Physician attitudes toward regionalization of adult critical care: A national survey.
Next Document:  Nutrient gene interactions in lipid metabolism.